2026-04-29T19:07:38Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/201842024-07-06T01:01:04Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Munoz-Perez, Elena
author
Rubio-Retama, J
author
Cussó, Lorena
author
Igartua, Manoli
author
Hernandez, Rosa Maria
author
Santos-Vizcaino, Edorta
funder
Ministerio de Ciencia e Innovación (España)
funder
Agencia Estatal de Investigación (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Comunidad de Madrid (España)
funder
Instituto de Salud Carlos III
2024-07-05T15:03:36Z
2024-07-05T15:03:36Z
2024-01-07
Drug Deliv Transl Res. 2024 Jan 7.
10.1007/s13346-023-01506-5
2190-3948
Drug delivery and translational research
38185776
http://hdl.handle.net/20.500.12105/20184
Traditional approaches to solid rectal therapies have halted progress, leading to a continual decline in the use of conventional suppositories. Additive manufacturing techniques have been recently explored as a suitable innovative tool for suppository fabrication. However, little advancement has been made in composition materials for 3D-printed suppository (3DPS) manufacturing and still, conventional vehicles are often used for construct fabrication, hindering the growth in the field. As a novelty, this study unveils a ground-breaking Laponite-alginate hydrogel-based 3DPS. Interestingly, this study proposes a novel approach for loading drugs into the 3DPS employing for the first time the post-printing loading. Thus, a passive loading strategy of molecular models is developed, demonstrating the versatility and capacity to load molecules of different charges and molecular sizes within the matrix systems. This novel strategy allows adapting the load of a wide range of drugs into a single ink, which simplifies and speeds up the 3DPS technological development process for drugs with different physico-chemical properties. Additionally, in this research, a displacement strategy of the three-dimensional Laponite matrices is developed in order to enhance the drug release capacity through the 3DPS and their disintegration capacity, resulting in a significant improvement of the drug diffusion through the hydrogel matrix and a rapid disintegration of the 3DPS. Finally, our study demonstrates that the obtained 3DPS have a suitable in vivo behavior, being non-obstructive and allowing the normal motility of the rats intestine.
eng
3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release.
journal article
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URL
https://repisalud.isciii.es/bitstreams/8682711e-a36b-4391-b2b2-a15663cbcbd9/download
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b0658a5c60b7966e330939f7680b9f0f
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3D_printed Laponite_Alginate hydrogel_Drug Deliv Transl Res_2024.pdf
URL
https://repisalud.isciii.es/bitstreams/0f00618d-aa3a-4b3c-84a7-dd8a5173b822/download
File
MD5
6314cdd8dcca063d14ef71cb7c3160e5
77046
text/plain
3D_printed Laponite_Alginate hydrogel_Drug Deliv Transl Res_2024.pdf.txt