2026-05-17T05:52:22Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/201792024-09-22T09:09:15Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16961col_20.500.12105_16967col_20.500.12105_16983
Repisalud author Martinez-Gonzalez, Miguel A author Zazpe, Itziar author Razquin, Cristina author Sanchez-Tainta, Ana author Corella, Dolores author Salas-Salvado, Jordi author Toledo, Estefanía author Ros, Emilio author Angel Munoz, Miguel author Recondo, Javier author Gomez-Gracia, Enrique author Fiol Sala, Miquel author Lapetra, Jose author Buil-Cosiales, Pilar author Serra-Majem, Lluis author Pinto, Xavier author Schroeder, Helmut author Tur, Josep A author Sorli, Jose V author Lamuela-Raventos, Rosa M author Estruch, Ramon author PREDIMED GRP 2024-07-04T12:56:42Z 2024-07-04T12:56:42Z 2015-10 Martinez-Gonzalez Miguel A., Zazpe Itziar, Razquin Cristina, Sanchez-Tainta Ana, Corella Dolores, Salas-Salvado Jordi, et al. Empirically-derived food patterns and the risk of total mortality and cardiovascular events in the PREDIMED study. Clin Nutr. 2015 Oct;34(5):859-867. Epub 2014 Sep 16. 10.1016/j.clnu.2014.09.006 1532-1983 0261-5614 Clinical Nutrition http://hdl.handle.net/20.500.13003/10681 25304294 L602650370 2-s2.0-84939259701 http://hdl.handle.net/20.500.12105/20179 360949800010 Background & aims: There is little evidence on post hoc-derived dietary patterns (DP) and all-cause mortality in Southern-European populations. Furthermore, the potential effect modification of a DP by a nutritional intervention has not been sufficiently assessed. We assessed the association between a posteriori defined baseline major DP and total mortality or cardiovascular events within each of the three arms of a large primary prevention trial (PREDIMED) where participants were randomized to two active interventions with Mediterranean-type diets or to a control group (allocated to a low-fat diet). Design: We followed-up 7216 participants for a median of 4.3 years. A validated 137-item food-frequency questionnaire was administered. Baseline DP were ascertained through factor analysis based on 34 predefined groups. Cox regression models were used to estimate multivariable-adjusted hazard ratios (HR) for cardiovascular disease (CVD) or mortality across quartiles of DP within each of the-three arms of the trial. Results: We identified two major baseline DP: the first DP was rich in red and processed meats, alcohol, refined grains and whole dairy products and was labeled Western dietary pattern (WDP). The second DP corresponded to a Mediterranean-type dietary pattern (MDP). During follow-up, 328 participants died. After controlling for potential confounders, higher baseline adherence to the MDP was associated with lower risk of CVD (adjusted HR for fourth vs. first quartile: 0.52; 95% Cl (Confidence Interval): 0.36, 0.74; p-trend <0.001) and all-cause mortality (adjusted HR: 0.53; 95% CI: 038, 0.75; p-trend <0.001), regardless of the allocated arm of the trial. An increasing mortality rate was found across increasing quartiles of the WDP in the control group (allocated to a low-fat diet), though the linear trend was not statistically significant (p = 0.098). Conclusions: Higher adherence to an empirically-derived MDP at baseline was associated with a reduced risk of CVD and mortality in the PREDIMED trial regardless of the allocated arm. The WDP was not associated with higher risk of mortality or cardiovascular events. eng Mediterranean diet Dietary pattern Mortality Cardiovascular risk PREDIMED Empirically-derived food patterns and the risk of total mortality and cardiovascular events in the PREDIMED study research article