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00925njm 22002777a 4500 dc Martinez-Gonzalez, Miguel A author Salas-Salvado, Jordi author Estruch, Ramon author Corella, Dolores author Fito, Montserrat author Ros, Emilio author PREDIMED INVESTIGATORS author 2015-07 The PREDIMED (PREvenciOn con DIeta MEDiterranea) multicenter, randomized, primary prevention trial assessed the long-term effects of the Mediterranean diet (MeDiet) on clinical events of cardiovascular disease (CVD). We randomized 7447 men and women at high CVD risk into three diets: MeDiet supplemented with extra-virgin olive oil (EVOO), MeDiet supplemented with nuts, and control diet (advice on a low-fat diet). No energy restriction and no special intervention on physical activity were applied. We observed 288 CVD events (a composite of myocardial infarction, stroke or CVD death) during a median time of 4.8 years; hazard ratios were 0.70 (95% CI, 0.53-0.91) for the MeDiet + EVOO and 0.70 (CI, 0.53-0.94) for the MeDiet + nuts compared to the control group. Respective hazard ratios for incident diabetes (273 cases) among 3541 non-diabetic participants were 0.60 (0.43-0.85) and 0.82 (0.61-1.10) for MeDiet + EVOO and MeDiet + nuts, respectively versus control. Significant improvements in classical and emerging CVD risk factors also supported a favorable effect of both MeDiets on blood pressure, insulin sensitivity, lipid profiles, lipoprotein particles, inflammation, oxidative stress, and carotid atherosclerosis. In nutrigenomic studies beneficial effects of the intervention with MedDiets showed interactions with several genetic variants (TCF7L2, APOA2, MLXIPL, LPL, FTO, M4CR, COX-2, GCKR and SERPINE1) with respect to intermediate and final phenotypes. Thus, the PREDIMED trial provided strong evidence that a vegetable-based MeDiet rich in unsaturated fat and polyphenols can be a sustainable and ideal model for CVD prevention. Martinez-Gonzalez Miguel A., Salas-Salvado Jordi, Estruch Ramon, Corella Dolores, Fito Montse, Ros Emilio, et al. Benefits of the Mediterranean Diet: Insights From the PREDIMED Study. Prog Cardiovasc Dis. 2015 Jul;58(1):50-60. Epub 2015 May 1. 10.1016/j.pcad.2015.04.003 1873-1740 0033-0620 Progress in Cardiovascular Diseases http://hdl.handle.net/20.500.13003/10805 25940230 L605274182 2-s2.0-84936938968 http://hdl.handle.net/20.500.12105/20178 357767000007 Mediterranean diet Dietary intervention Randomized trials Primary prevention Atrial fibrillation Peripheral artery disease Stroke Type-2 diabetes Benefits of the Mediterranean Diet: Insights From the PREDIMED Study