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oai:repisalud.isciii.es:20.500.12105/201762024-11-28T22:07:23Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967col_20.500.12105_16983

00925njm 22002777a 4500 dc Eguaras, Sonia author Toledo, Estefanía author Buil-Cosiales, P author Salas-Salvado, J author Corella, Dolores author Gutierrez-Bedmar, M author Santos-Lozano, J. M author Aros, F author Fiol Sala, Miquel author Fito Manteca, Maria Concepcion author Ros, E author Serra-Majem, L author Pinto, X author Martinez, JA author Sorli, JV author Munoz, MA author Basora, J author Estruch, Ramon author Martinez-Gonzalez, MA author PREDIMED Investigators author 2015-06 Background and aim: We tested the hypothesis that an intervention with a Mediterranean diet (MeDiet) could mitigate the well-known harmful effects of abdominal obesity on cardiovascular health. Methods and results: We assessed the relationship between baseline waist-to-height ratio (WHtR) and major cardiovascular events during a median follow-up of 4.8 years in the Prevention with Mediterranean Diet (PREDIMED) randomized primary prevention trial, which tested a MeDiet against a control diet (advice on a low-fat diet). We also examined whether the MeDiet intervention was able to counteract the detrimental cardiovascular effects of an increased WHtR. The trial included 7447 participants (55-80 years old, 57% women) at high cardiovascular risk but free of cardiovascular disease (CVD) at enrollment. An increased risk of CVD events (myocardial infarction, stroke, or cardiovascular death) was apparent for the highest versus the lowest quartile of WHtR (multivariable-adjusted hazard ratio: 1.98) (95% confidence interval: 1.10-3.57; linear trend: p = 0.019) only in the control-diet group, but not in the two groups allocated to intervention with MeDiet (p for interaction = 0.034). This apparent interaction suggesting that the intervention counterbalanced the detrimental cardiovascular effects of adiposity was also significant for body mass index (BMI) (p = 0.01) and waist circumference (p = 0.043). Conclusions: The MeDiet may counteract the harmful effects of increased adiposity on the risk of CVD. Eguaras S., Toledo E., Buil-Cosiales P., Salas-Salvado J., Corella D., Gutierrez-Bedmar M., et al. Does the Mediterranean diet counteract the adverse effects of abdominal adiposity?. Nutr Metab Carbiovasc Dis. 2015 Jun;25(6):569-574. Epub 2015 Mar 11. 10.1016/j.numecd.2015.03.001 1590-3729 0939-4753 Nutrition Metabolism and Cardiovascular Diseases http://hdl.handle.net/20.500.13003/10833 25921850 L603966837 2-s2.0-84930182869 http://hdl.handle.net/20.500.12105/20176 355153700008 Waist-to-height ratio Mediterranean diet Dietary intervention Cardiovascular disease Does the Mediterranean diet counteract the adverse effects of abdominal adiposity?