2026-06-14T05:06:05Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/201742024-07-04T12:56:39Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16961col_20.500.12105_16967

00925njm 22002777a 4500 dc Sabater, Sebastia author Arenas, Meritxell author Berenguer, Roberto author Andres, Ignacio author Jiménez-Jiménez, Esther author Martos, Ana author Fernandez-Lopez, Jesus author Sevillano, Mar author Rovirosa, Angeles author 2015-07 Purpose: Association between body mass index (BMI) and doses in organs at risk during postoperative vaginal cuff brachytherapy (VCB) treatment has not been evaluated. The aim of this study was to analyse the impact of BMI on the dose delivered to bladder and rectum during high-dose-rate VCB using computed tomography (CT) scans at every fraction. Materials and Methods: A retrospective analysis of 220 planning CT sets derived from 59 patients was conducted. Every planning CT was re-segmented and re-planned under the same parameters. Rectum and bladder dose-volume histogram values (D-0.1cc, D-1cc, and D-2cc) were extracted and evaluated. The mean values for all applications per patient were calculated and correlated with BMI, as well as other factors influencing rectal and bladder doses. Multiple regression analysis performed to model organ at risk dose-volume parameters. Results: According to World Health Organization (WHO), 6.8% of patients were normal, 35.6% were overweight, and 57.6% were class I obese. Median rectal doses were 133.5%, 110.9%, and 99.3% for D-0.1cc, D-1cc, and D-2cc, respectively. The corresponding median bladder doses were 96.2%, 80.6%, and 73.3%, respectively. BMI did not show significant association with rectal doses. However, BMI did show a significant association with evaluated bladder dose metrics (D-0.1cc, r=-0.366, p=0.004; D-1cc, r=-0.454, p < 0.001; D-2cc, r=-0.451, p < 0.001). BMI was retained in the multivariate regression models (D-0.1cc, p=0.004; D-1cc, p < 0.001; D-2cc, p=0.001). Conclusion: In this group of Mediterranean, overweight, and moderately obese patients, BMI showed association with lower bladder dose values, but not with rectal doses. Sabater S, Arenas M, Berenguer R, Andres I, Jimenez-Jimenez E, Martos A, et al. Body Mass Index and Doses at Organs at Risk in a Mediterranean Population Treated with Postoperative Vaginal Cuff Brachytherapy. Cancer Res Treat. 2015 Jul;47(3):473-9. Epub 2014 Nov 24. 10.4143/crt.2014.115 2005-9256 1598-2998 Cancer Research and Treatment http://hdl.handle.net/20.500.13003/11437 25672575 L605229227 2-s2.0-84937148521 http://hdl.handle.net/20.500.12105/20174 357874900015 Body mass index Obesity Brachytherapy Urinary bladder Rectum Body Mass Index and Doses at Organs at Risk in a Mediterranean Population Treated with Postoperative Vaginal Cuff Brachytherapy