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oai:repisalud.isciii.es:20.500.12105/201652024-11-29T02:50:23Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Nozhenko, Yuriy author Asnani-Kishnani, Madhu author Rodriguez, Ana M author Palou, Andreu author 2015-12-17 A significant number of chronic diseases are linked to perinatal nutrition, and prevention may be associated to naturally occurring components of breast milk. One key hormone in breast milk is leptin, related with the protection from obesity in the adulthood, thus knowing its changes through the day or lactation is crucial. We aimed to investigate the daily rhythms in the milk levels of leptin, together with other two related hormones, ghrelin and adiponectin, during lactation (days 5, 10 and 15) in rat dams, and the relation with morphometric parameters (dams and pups). Summarizing the main results, the existence of biological rhythms, but not daily and maybe circasemidian, was confirmed for the three hormones at the earliest period of lactation. The correlations performed generally showed a possible dependence of milk hormone levels on plasma levels at the early phase of lactation, while with the progression of lactation this dependence may fade and the hormone levels are suggested to be more dependent on mammary gland production/maturation. There was also a correlation between milk leptin and adiponectin levels, especially in the first half of lactation, suggesting a possible parallel regulation. Interestingly, we describe a milk leptin surge around the mid of lactation (at day 10) which may be related with pup's growth (males and females) and with the well-known (in the literature) plasma leptin surge in pups. All this knowledge may be crucial for future applications in the development of formula milk and in relation with the role of leptin surge during lactation. Nozhenko Y, Asnani-Kishnani M, Rodriguez Guerrero AM, Palou Oliver A. Milk Leptin Surge and Biological Rhythms of Leptin and Other Regulatory Proteins in Breastmilk. PLoS One. 2015 Dec 17;10(12):e0145376. 10.1371/journal.pone.0145376 1932-6203 PloS One http://hdl.handle.net/20.500.13003/10575 26680765 L608056328 2-s2.0-84956910847 http://hdl.handle.net/20.500.12105/20165 366723400073 Milk Leptin Surge and Biological Rhythms of Leptin and Other Regulatory Proteins in Breastmilk