2026-07-21T14:20:02Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/201552024-11-29T01:44:52Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Cuervo, Guillermo
author
Camoez, Mariana
author
Shaw, Evelyn
author
Angeles Dominguez, Maria
author
Gasch, Oriol
author
Padilla, Belen
author
Pintado, Vicente
author
Almirante, Benito
author
Molina, Jose
author
Lopez-Medrano, Francisco
author
Ruiz de Gopegui-Bordes, Enrique
author
Martinez, Jose A
author
Bereciartua, Elena
author
Rodriguez-Lopez, Fernando
author
Fernandez-Mazarrasa, Carlos
author
Angel Goenaga, Miguel
author
Benito, Natividad
author
Rodriguez-Bano, Jesus
author
Espejo, Elena
author
Pujol, Miquel
author
REIPI GEIH Study Grp
2024-07-04T12:56:32Z
2024-07-04T12:56:32Z
2015-10-30
Cuervo G, Camoez M, Shaw E, Dominguez MA, Gasch O, Padilla B, et al. Methicillin-resistant Staphylococcus aureus (MRSA) catheter-related bacteraemia in haemodialysis patients. BMC Infect Dis. 2015 Oct 30;15:484.
10.1186/s12879-015-1227-y
1471-2334
BMC Infectious Diseases
http://hdl.handle.net/20.500.13003/10657
26518487
L606719322
2-s2.0-84945907463
http://hdl.handle.net/20.500.12105/20155
364278200001
Background: The aim of the study was to determine clinical and microbiological differences between patients with methicillin-resistant Staphylococcus aureus (MRSA) catheter-related bacteraemia (CRB) undergoing or not undergoing haemodialysis, and to compare outcomes. Methods: Prospective multicentre study conducted at 21 Spanish hospitals of patients with MRSA bacteraemia diagnosed between June 2008 and December 2009. Patients with MRSA-CRB were selected. Data of patients on haemodialysis (HD-CRB) and those not on haemodialysis (non-HD-CRB) were compared. Results: Among 579 episodes of MRSA bacteraemia, 218 (37.7 %) were CRB. Thirty-four (15.6 %) were HD-CRB and 184 (84.4 %) non-HD-CRB. All HD-CRB patients acquired the infection at dialysis centres, while in 85.3 % of the non-HD-CRB group the infection was nosocomial (p < .001). There were no differences in age, gender or severity of bacteraemia (Pitt score); comorbidities (Charlson score >= 4) were higher in the HD-CRB group than in the non-HD-CRB group (73.5 % vs. 46.2 %, p = .003). Although there were no differences in VAN-MIC >= 1.5 mg/L according to microdilution, using the E-test a higher rate of VAN-MIC >= 1.5 mg/L was observed in HD-CRB than in non-HD-CRB patients (63.3 % vs. 44.1 %, p = .051). Vancomycin was more frequently administered in the HD-CRB group than in the non-HD-CRB group (82.3 % vs. 42.4 %, p = <. 001) and therefore the appropriate empirical therapy was significantly higher in HD-CRB group (91.2 % vs. 73.9 %, p = .029). There were no differences with regard to catheter removal (79.4 % vs. 84.2 %, p = .555, respectively). No significant differences in mortality rate were observed between both groups (Overall mortality: 11.8 % vs. 27.2 %, p = .081, respectively), but there was a trend towards a higher recurrence rate in HD-CRB group (8.8 % vs. 2.2 %, p = .076). Conclusions: In our multicentre study, ambulatory patients in chronic haemodialysis represented a significant proportion of cases of MRSA catheter-related bacteraemia. Although haemodialysis patients with MRSA catheter-related bacteraemia had significantly more comorbidities and higher proportion of strains with reduced vancomycin susceptibility than non-haemodialysis patients, overall mortality between both groups was similar.
eng
Bacteraemia
Catheter-related
Haemodialysis
MRSA
Methicillin-resistant Staphylococcus aureus (MRSA) catheter-related bacteraemia in haemodialysis patients
research article