2026-05-10T16:19:54Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/201542024-11-28T18:07:45Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16961col_20.500.12105_16967col_20.500.12105_16978col_20.500.12105_16984
Repisalud
author
Noriega, Victor
author
Martinez-Laperche, Carolina
author
Buces, Elena
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Sanchez-Hernandez, Noemi
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Martin-Antonio, Beatriz
author
Guillem, Vicent
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Bosch-Vizcaya, Anna
author
Bento, Leyre
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Gonzalez-Rivera, Milagros
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Balsalobre, Pascual
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Kwon, Mi
author
Serrano, David
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Gayoso, Jorge
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de la Cámara, Rafael
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Brunet, Salut
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Rojas-Contreras, Rafael
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Nieto, Jose B.
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Martinez, Carmen
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Gonzalez, Marcos
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Espigado, Ildefonso
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Vallejo, Juan C.
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Sampol Mayol, Antonia
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Jimenez-Velasco, Antonio
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Urbano-Ispizua, Alvaro
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Solano, Carlos
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Gallardo, David
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Diez-Martin, Jose L
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Buno, Ismael
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Spanish Hematopoietic Stem Cell Tr
2024-07-04T12:56:31Z
2024-07-04T12:56:31Z
2015-10-16
Noriega V, Martinez-Laperche C, Buces E, Pion M, Sanchez-Hernandez N, Martin-Antonio B, et al. The Genotype of the Donor for the (GT)(n) Polymorphism in the Promoter/Enhancer of FOXP3 Is Associated with the Development of Severe Acute GVHD but Does Not Affect the GVL Effect after Myeloablative HLA-Identical Allogeneic Stem Cell Transplantation. PLoS One. 2015 Oct 16;10(10):e0140454.
10.1371/journal.pone.0140454
1932-6203
PloS One
http://hdl.handle.net/20.500.13003/10659
26473355
L607132865
2-s2.0-84949220859
http://hdl.handle.net/20.500.12105/20154
363185500054
The FOXP3 gene encodes for a protein (Foxp3) involved in the development and functional activity of regulatory T cells (CD4+/CD25+/Foxp3+), which exert regulatory and suppressive roles over the immune system. After allogeneic stem cell transplantation, regulatory T cells are known to mitigate graft versus host disease while probably maintaining a graft versus leukemia effect. Short alleles (<=(GT)(15)) for the (GT)(n) polymorphism in the promoter/enhancer of FOXP3 are associated with a higher expression of FOXP3, and hypothetically with an increase of regulatory T cell activity. This polymorphism has been related to the development of auto-or alloimmune conditions including type 1 diabetes or graft rejection in renal transplant recipients. However, its impact in the allo-transplant setting has not been analyzed. In the present study, which includes 252 myeloablative HLA-identical allo-transplants, multivariate analysis revealed a lower incidence of grade III-IV acute graft versus host disease (GVHD) in patients transplanted from donors harboring short alleles (OR = 0.26, CI 0.08-0.82, p = 0.021); without affecting chronic GVHD or graft versus leukemia effect, since cumulative incidence of relapse, event free survival and overall survival rates are similar in both groups of patients.
eng
The Genotype of the Donor for the (GT)(n) Polymorphism in the Promoter/Enhancer of FOXP3 Is Associated with the Development of Severe Acute GVHD but Does Not Affect the GVL Effect after Myeloablative HLA-Identical Allogeneic Stem Cell Transplantation
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