2026-06-14T06:44:07Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/201322024-11-29T07:20:35Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Cosmo, Camila
author
Baptista, Abrahao Fontes
author
de Araujo, Arao Nogueira
author
do Rosario, Raphael Silva
author
Vivas Miranda, Jose Garcia
author
Montoya, Pedro
author
de Sena, Eduardo Ponde
2024-07-04T12:56:22Z
2024-07-04T12:56:22Z
2015-08-12
Cosmo C, Baptista Abrahao F, De Araujo Arao N, Do Rosario RS, Vivas Miranda JG, Montoya P, et al. A Randomized, Double-Blind, Sham-Controlled Trial of Transcranial Direct Current Stimulation in Attention-Deficit/Hyperactivity Disorder. PLoS One. 2015 Aug 12;10(8):e0135371.
10.1371/journal.pone.0135371
1932-6203
PloS One
http://hdl.handle.net/20.500.13003/10752
26267861
L606195682
2-s2.0-84942945230
http://hdl.handle.net/20.500.12105/20132
359492300108
Background: Current standardized treatments for cognitive impairment in attention-deficit/hyperactivity disorder remain limited and their efficacy restricted. Transcranial direct current stimulation (tDCS) is a promising tool for enhancing cognitive performance in several neuropsychiatric disorders. Nevertheless, the effects of tDCS in reducing cognitive impairment in patients with attention-deficit/hyperactivity disorder (ADHD) have not yet been investigated. Methods: A parallel, randomized, double-blind, sham-controlled trial was conducted to examine the efficacy of tDCS on the modulation of inhibitory control in adults with ADHD. Thirty patients were randomly allocated to each group and performed a go/no-go task before and after a single session of either anodal stimulation (1 mA) over the left dorsolateral prefrontal cortex or sham stimulation. Results: A nonparametric two-sample Wilcoxon rank-sum (Mann-Whitney) test revealed no significant differences between the two groups of individuals with ADHD (tDCS vs. sham) in regard to behavioral performance in the go/no go tasks. Furthermore, the effect sizes of group differences after treatment for the primary outcome measures-correct responses, impulsivity and omission errors-were small. No adverse events resulting from stimulation were reported. Conclusion: According to these findings, there is no evidence in support of the use of anodal stimulation over the left dorsolateral prefrontal cortex as an approach for improving inhibitory control in ADHD patients. To the best of our knowledge, this is the first clinical study to assess the cognitive effects of tDCS in individuals with ADHD. Further research is needed to assess the clinical efficacy of tDCS in this population.
eng
A Randomized, Double-Blind, Sham-Controlled Trial of Transcranial Direct Current Stimulation in Attention-Deficit/Hyperactivity Disorder
research article