2026-07-21T13:56:06Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/201062024-11-29T06:20:52Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Barcelo, Francisca
author
Cerda, Joan J.
author
Gutierrez, Antonio
author
Jimenez-Marco, Teresa
author
Duran Pastor, Maria Antonia
author
Novo, Andrés
author
Ros, Teresa
author
Sampol Mayol, Antonia
author
Portugal, Jose
2024-07-04T12:54:56Z
2024-07-04T12:54:56Z
2015-03-20
Barcelo F, Cerda JJ, Gutierrez A, Jimenez-Marco T, Duran Pastor MA, Novo García A, et al. Characterization of Monoclonal Gammopathy of Undetermined Significance by Calorimetric Analysis of Blood Serum Proteome. PLoS One. 2015 Mar 20;10(3):e0120316.
10.1371/journal.pone.0120316
1932-6203
PloS One
http://hdl.handle.net/20.500.13003/10906
25794164
L603270889
2-s2.0-84925745412
http://hdl.handle.net/20.500.12105/20106
352083900011
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant proliferative disorder that may progress to multiple myeloma, a malignant plasma cell neoplasia. We evaluated differential scanning calorimetry (DSC) as an experimental tool for differentiating serum samples of MGUS patients from healthy individuals. DSC thermograms can be used for monitoring changes in the serum proteome associated with MGUS. MGUS patients showed great variability in serum thermogram characteristics, which depended on the IgG, IgA or IgM iso-types and/or the. or. light chains. Thermogram feature parameters distinguished patients with MGUS from healthy people. Serum samples, named as non-MGUS, were also collected from patients with subjacent immunological pathologies who were discarded of having MGUS through serum immunofixation. They were used to verify the sensitivity of DSC for discriminating MGUS from related blood dyscrasias. Only some DSC thermogram feature parameters differentiated, to a lesser extent, between MGUS and non-MGUS individuals. We contemplate DSC as a tool for early diagnosis and monitoring of MGUS.
eng
Characterization of Monoclonal Gammopathy of Undetermined Significance by Calorimetric Analysis of Blood Serum Proteome
research article