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oai:repisalud.isciii.es:20.500.12105/201062024-11-29T06:20:52Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Barcelo, Francisca author Cerda, Joan J. author Gutierrez, Antonio author Jimenez-Marco, Teresa author Duran Pastor, Maria Antonia author Novo, Andrés author Ros, Teresa author Sampol Mayol, Antonia author Portugal, Jose author 2015-03-20 Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant proliferative disorder that may progress to multiple myeloma, a malignant plasma cell neoplasia. We evaluated differential scanning calorimetry (DSC) as an experimental tool for differentiating serum samples of MGUS patients from healthy individuals. DSC thermograms can be used for monitoring changes in the serum proteome associated with MGUS. MGUS patients showed great variability in serum thermogram characteristics, which depended on the IgG, IgA or IgM iso-types and/or the. or. light chains. Thermogram feature parameters distinguished patients with MGUS from healthy people. Serum samples, named as non-MGUS, were also collected from patients with subjacent immunological pathologies who were discarded of having MGUS through serum immunofixation. They were used to verify the sensitivity of DSC for discriminating MGUS from related blood dyscrasias. Only some DSC thermogram feature parameters differentiated, to a lesser extent, between MGUS and non-MGUS individuals. We contemplate DSC as a tool for early diagnosis and monitoring of MGUS. Barcelo F, Cerda JJ, Gutierrez A, Jimenez-Marco T, Duran Pastor MA, Novo García A, et al. Characterization of Monoclonal Gammopathy of Undetermined Significance by Calorimetric Analysis of Blood Serum Proteome. PLoS One. 2015 Mar 20;10(3):e0120316. 10.1371/journal.pone.0120316 1932-6203 PloS One http://hdl.handle.net/20.500.13003/10906 25794164 L603270889 2-s2.0-84925745412 http://hdl.handle.net/20.500.12105/20106 352083900011 Characterization of Monoclonal Gammopathy of Undetermined Significance by Calorimetric Analysis of Blood Serum Proteome