2026-06-14T12:13:09Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/201012025-04-24T12:26:07Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16962col_20.500.12105_16967col_20.500.12105_16974
Repisalud
author
Chajes, Veronique
author
Biessy, Carine
author
Ferrari, Pietro
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Romieu, Isabelle
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Freisling, Heinz
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Huybrechts, Inge
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Scalbert, Augustin
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de Mesquita, Bas Bueno
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Romaguera, Dora
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Gunter, Marc J
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Vineis, Paolo
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Plambeck Hansen, Camilla
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Uhre Jakobsen, Marianne
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Clavel-Chapelon, Francoise
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Fagherazzi, Guy
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Boutron-Ruault, Marie-Christine
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Katzke, Verana
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Neamat-Allah, Jasmine
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Boeing, Heiner
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Bachlechner, Ursula
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Trichopoulou, Antonia
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Naska, Androniki
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Orfanos, Philippos
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Pala, Valeria
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Masala, Giovanna
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Mattiello, Amalia
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Skeie, Guri
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Weiderpass, Elisabete
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Agudo, Antonio
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Huerta, José María
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Ardanaz, Eva
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Sanchez, Maria Jose
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Dorronsoro, Miren
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Quiros, Jose Ramon
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Johansson, Ingegerd
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Winkvist, Anna
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Sonested, Emily
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Key, Tim
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Khaw, Kay-Tee
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Wareham, Nicolas J.
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Peeters, Petra H. M.
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Slimani, Nadia
2024-07-04T12:54:54Z
2024-07-04T12:54:54Z
2015-02-12
Chajes V, Biessy C, Ferrari P, Romieu I, Freisling H, Huybrechts I, et al. Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study. PLoS One. 2015 Feb 12;10(2):e0118206.
10.1371/journal.pone.0118206
1932-6203
PloS One
http://hdl.handle.net/20.500.13003/10940
25675445
L602263356
2-s2.0-84923112413
http://hdl.handle.net/20.500.12105/20101
349914000043
Background: Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition ( EPIC) cohort. Methods: Baseline plasma fatty acid concentrations were determined in a representative EPIC sample from the 23 participating EPIC centers. A total of 1,945 individuals were followed for a median of 4.9 years to monitor weight change. The association between elaidic acid level and percent change of weight was investigated using a multinomial logistic regression model, adjusted by length of follow- up, age, energy, alcohol, smoking status, physical activity, and region. Results: In women, doubling elaidic acid was associated with a decreased risk of weight loss ( odds ratio ( OR) = 0.69, 95% confidence interval ( CI) = 0.55- 0.88, p = 0.002) and a trend was observed with an increased risk of weight gain during the 5- year follow- up ( OR = 1.23, 95% CI = 0.97- 1.56, p = 0.082) ( p- trend<. 0001). In men, a trend was observed for doubling elaidic acid level and risk of weight loss ( OR = 0.82, 95% CI = 0.66- 1.01, p = 0.062) while no significant association was found with risk of weight gain during the 5- year follow- up ( OR = 1.08, 95% CI = 0.88- 1.33, p = 0.454). No association was found for saturated and cismonounsaturated fatty acids. Conclusions: These data suggest that a high intake of industrial trans fatty acids may decrease the risk of weight loss, particularly in women. Prevention of obesity should consider limiting the consumption of highly processed foods, the main source of industrially- produced trans fatty acids.
eng
Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study
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