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00925njm 22002777a 4500 dc Chajes, Veronique author Biessy, Carine author Ferrari, Pietro author Romieu, Isabelle author Freisling, Heinz author Huybrechts, Inge author Scalbert, Augustin author de Mesquita, Bas Bueno author Romaguera, Dora author Gunter, Marc J author Vineis, Paolo author Plambeck Hansen, Camilla author Uhre Jakobsen, Marianne author Clavel-Chapelon, Francoise author Fagherazzi, Guy author Boutron-Ruault, Marie-Christine author Katzke, Verana author Neamat-Allah, Jasmine author Boeing, Heiner author Bachlechner, Ursula author Trichopoulou, Antonia author Naska, Androniki author Orfanos, Philippos author Pala, Valeria author Masala, Giovanna author Mattiello, Amalia author Skeie, Guri author Weiderpass, Elisabete author Agudo, Antonio author Huerta, José María author Ardanaz, Eva author Sanchez, Maria Jose author Dorronsoro, Miren author Quiros, Jose Ramon author Johansson, Ingegerd author Winkvist, Anna author Sonested, Emily author Key, Tim author Khaw, Kay-Tee author Wareham, Nicolas J. author Peeters, Petra H. M. author Slimani, Nadia author 2015-02-12 Background: Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition ( EPIC) cohort. Methods: Baseline plasma fatty acid concentrations were determined in a representative EPIC sample from the 23 participating EPIC centers. A total of 1,945 individuals were followed for a median of 4.9 years to monitor weight change. The association between elaidic acid level and percent change of weight was investigated using a multinomial logistic regression model, adjusted by length of follow- up, age, energy, alcohol, smoking status, physical activity, and region. Results: In women, doubling elaidic acid was associated with a decreased risk of weight loss ( odds ratio ( OR) = 0.69, 95% confidence interval ( CI) = 0.55- 0.88, p = 0.002) and a trend was observed with an increased risk of weight gain during the 5- year follow- up ( OR = 1.23, 95% CI = 0.97- 1.56, p = 0.082) ( p- trend<. 0001). In men, a trend was observed for doubling elaidic acid level and risk of weight loss ( OR = 0.82, 95% CI = 0.66- 1.01, p = 0.062) while no significant association was found with risk of weight gain during the 5- year follow- up ( OR = 1.08, 95% CI = 0.88- 1.33, p = 0.454). No association was found for saturated and cismonounsaturated fatty acids. Conclusions: These data suggest that a high intake of industrial trans fatty acids may decrease the risk of weight loss, particularly in women. Prevention of obesity should consider limiting the consumption of highly processed foods, the main source of industrially- produced trans fatty acids. Chajes V, Biessy C, Ferrari P, Romieu I, Freisling H, Huybrechts I, et al. Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study. PLoS One. 2015 Feb 12;10(2):e0118206. 10.1371/journal.pone.0118206 1932-6203 PloS One http://hdl.handle.net/20.500.13003/10940 25675445 L602263356 2-s2.0-84923112413 http://hdl.handle.net/20.500.12105/20101 349914000043 Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study