2026-06-14T05:05:38Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/200902024-11-28T19:35:25Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud author Solis-Calero, Christian author Ortega-Castro, Joaquin author Frau, Juan author Munoz, Francisco 2024-07-04T12:54:50Z 2024-07-04T12:54:50Z 2015 Solis-Calero C, Ortega-Castro J, Frau J, Muñoz Izquierdo F. Nonenzymatic Reactions above Phospholipid Surfaces of Biological Membranes: Reactivity of Phospholipids and Their Oxidation Derivatives. Oxidative Med Cell Longev. 2015;2015:319505. Epub 2015 Apr 21. 10.1155/2015/319505 1942-0994 1942-0900 Oxidative Medicine and Cellular Longevity http://hdl.handle.net/20.500.13003/10992 25977746 L604314823 2-s2.0-84929377972 http://hdl.handle.net/20.500.12105/20090 354738200001 Phospholipids play multiple and essential roles in cells, as components of biological membranes. Although phospholipid bilayers provide the supporting matrix and surface for many enzymatic reactions, their inherent reactivity and possible catalytic role have not been highlighted. As other biomolecules, phospholipids are frequent targets of nonenzymatic modifications by reactive substances including oxidants and glycating agents which conduct to the formation of advanced lipoxidation end products (ALEs) and advanced glycation end products (AGEs). There are some theoretical studies about the mechanisms of reactions related to these processes on phosphatidylethanolamine surfaces, which hypothesize that cell membrane phospholipids surface environment could enhance some reactions through a catalyst effect. On the other hand, the phospholipid bilayers are susceptible to oxidative damage by oxidant agents as reactive oxygen species (ROS). Molecular dynamics simulations performed on phospholipid bilayers models, which include modified phospholipids by these reactions and subsequent reactions that conduct to formation of ALEs and AGEs, have revealed changes in the molecular interactions and biophysical properties of these bilayers as consequence of these reactions. Then, more studies are desirable which could correlate the biophysics of modified phospholipids with metabolism in processes such as aging and diseases such as diabetes, atherosclerosis, and Alzheimer's disease. eng Nonenzymatic Reactions above Phospholipid Surfaces of Biological Membranes: Reactivity of Phospholipids and Their Oxidation Derivatives review article