2026-08-10T01:34:25Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/200852025-04-30T11:19:52Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967col_20.500.12105_16974
Repisalud
author
Navarrete-Muñoz, Eva María
author
Valera-Gran, Desiree
author
Garcia de la Hera, Manoli
author
Gimenez-Monzo, Daniel
author
Morales, Eva
author
Julvez, Jordi
author
Riano, Isolina
author
Tardon, Adonina
author
Ibarluzea, Jesus
author
Santa-Marina, Loreto
author
Murcia, Mario
author
Rebagliato, Marisa
author
INMA Project
2024-07-04T12:54:48Z
2024-07-04T12:54:48Z
2015
Navarrete-Muñoz EM, Valera-Gran D, Garcia De La Hera M, Gimenez-Monzo D, Morales E, Julvez J, et al. Use of high doses of folic acid supplements in pregnant women in Spain: an INMA cohort study. BMJ Open. 2015;5(11):e009202.
10.1136/bmjopen-2015-009202
2044-6055
BMJ Open
http://hdl.handle.net/20.500.13003/17188
26603248
L613789174
2-s2.0-85006817994
http://hdl.handle.net/20.500.12105/20085
368840100120
Objectives: We examined the use of low (<400 mu g/day, including no use) and high folic acid supplement (FAS) dosages (>= 1000 mu g/day) among pregnant women in Spain, and explored factors associated with the use of these non-recommended dosages. Design: Population-based cohort study. Setting: Spain. Participants: We analysed data from 2332 pregnant women of the INMA study, a prospective mother-child cohort study in Spain. Main outcome measures: We assessed usual dietary folate and the use of FAS from preconception to the 3rd month (first period) and from the 4th to the 7th month (second period), using a validated food frequency questionnaire. We used multinomial logistic regression to estimate relative risk ratios (RRRs). Results: Over a half of the women used low dosages of FAS in the first and second period while 29% and 17% took high dosages of FAS, respectively. In the first period, tobacco smoking (RRR=1.63), alcohol intake (RRR=1.40), multiparous (RRR=1.44), unplanned pregnancy (RRR=4.20) and previous spontaneous abortion (RRR=0.58, lower use of high FAS dosages among those with previous abortions) were significantly associated with low FAS dosages. Alcohol consumption (RRR=1.42), unplanned pregnancy (RRR=2.66) and previous spontaneous abortion (RRR=0.68) were associated with high dosage use. In the second period, only tobacco smoking was significantly associated with high FAS dosage use (RRR=0.67). Conclusions: A high proportion of pregnant women did not reach the recommended dosages of FAS in periconception and a considerable proportion also used FAS dosages >= 1000 mu g/day. Action should be planned by the Health Care System and health professionals to improve the appropriate periconceptional use of FAS, taking into consideration the associated factors.
eng
Use of high doses of folic acid supplements in pregnant women in Spain: an INMA cohort study
research article