2026-08-10T01:24:33Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/200852025-04-30T11:19:52Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967col_20.500.12105_16974

00925njm 22002777a 4500 dc Navarrete-Muñoz, Eva María author Valera-Gran, Desiree author Garcia de la Hera, Manoli author Gimenez-Monzo, Daniel author Morales, Eva author Julvez, Jordi author Riano, Isolina author Tardon, Adonina author Ibarluzea, Jesus author Santa-Marina, Loreto author Murcia, Mario author Rebagliato, Marisa author INMA Project author 2015 Objectives: We examined the use of low (<400 mu g/day, including no use) and high folic acid supplement (FAS) dosages (>= 1000 mu g/day) among pregnant women in Spain, and explored factors associated with the use of these non-recommended dosages. Design: Population-based cohort study. Setting: Spain. Participants: We analysed data from 2332 pregnant women of the INMA study, a prospective mother-child cohort study in Spain. Main outcome measures: We assessed usual dietary folate and the use of FAS from preconception to the 3rd month (first period) and from the 4th to the 7th month (second period), using a validated food frequency questionnaire. We used multinomial logistic regression to estimate relative risk ratios (RRRs). Results: Over a half of the women used low dosages of FAS in the first and second period while 29% and 17% took high dosages of FAS, respectively. In the first period, tobacco smoking (RRR=1.63), alcohol intake (RRR=1.40), multiparous (RRR=1.44), unplanned pregnancy (RRR=4.20) and previous spontaneous abortion (RRR=0.58, lower use of high FAS dosages among those with previous abortions) were significantly associated with low FAS dosages. Alcohol consumption (RRR=1.42), unplanned pregnancy (RRR=2.66) and previous spontaneous abortion (RRR=0.68) were associated with high dosage use. In the second period, only tobacco smoking was significantly associated with high FAS dosage use (RRR=0.67). Conclusions: A high proportion of pregnant women did not reach the recommended dosages of FAS in periconception and a considerable proportion also used FAS dosages >= 1000 mu g/day. Action should be planned by the Health Care System and health professionals to improve the appropriate periconceptional use of FAS, taking into consideration the associated factors. Navarrete-Muñoz EM, Valera-Gran D, Garcia De La Hera M, Gimenez-Monzo D, Morales E, Julvez J, et al. Use of high doses of folic acid supplements in pregnant women in Spain: an INMA cohort study. BMJ Open. 2015;5(11):e009202. 10.1136/bmjopen-2015-009202 2044-6055 BMJ Open http://hdl.handle.net/20.500.13003/17188 26603248 L613789174 2-s2.0-85006817994 http://hdl.handle.net/20.500.12105/20085 368840100120 Use of high doses of folic acid supplements in pregnant women in Spain: an INMA cohort study