2026-06-14T06:44:25Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/200832024-07-04T12:54:47Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16961col_20.500.12105_16967
Repisalud
author
Lopez, Aurelio
author
Mateos, Maria-Victoria
author
Oriol, Albert
author
Valero, Marta
author
Martinez, Joaquin
author
Lorenzo, Jose Ignacio
author
Perez, Montserrat
author
Martinez, Rafael
author
de Paz, Raquel
author
Granell, Miguel
author
de Arriba, Felipe
author
Blanchard, M Jesus
author
Penalver, Francisco-Javier
author
Bello, Jose Luis
author
Martin, Maria Luisa
author
Bargay Lleonart, Joan
author
Blade, Joan
author
Lahuerta, Juan Jose
author
San Miguel, Jesus F
author
de la Rubia Comos, Javier
2024-07-04T12:54:47Z
2024-07-04T12:54:47Z
2015
Lopez A, Mateos MV, Oriol A, Valero M, Martinez J, Lorenzo JI, et al. Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations.. Leuk Res Rep. 2015;4(2):64-9.
10.1016/j.lrr.2015.09.002
2213-0489
Leukemia Research Reports
http://hdl.handle.net/20.500.13003/17426
26500850
L606143667
2-s2.0-84942514302
http://hdl.handle.net/20.500.12105/20083
We report the characteristics of relapse, treatment response, and outcomes of 145 elderly patients with multiple myeloma in first relapse after front-line treatment with VMP or VTP. Reappearance of CRAB symptoms (113 patients) and more aggressive forms of disease (32 patients) were the most common patterns of relapse. After second-line therapy, 75 (51.7%) patients achieved at partial response and 16 (11%) complete response (CR). Overall survival was longer among patients receiving VMP as front-line induction (21.4 vs. 14.4 months, P=0.037), in patients achieving CR (28.3 vs. 14.8 months; P=0.04), and in patients without aggressive relapse (28.6 vs. 7.6 months; P=0.0007).
eng
Elderly patients
Patterns of relapse
Relapsed myeloma
Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations.
research article