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oai:repisalud.isciii.es:20.500.12105/200832024-07-04T12:54:47Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16961col_20.500.12105_16967

00925njm 22002777a 4500 dc Lopez, Aurelio author Mateos, Maria-Victoria author Oriol, Albert author Valero, Marta author Martinez, Joaquin author Lorenzo, Jose Ignacio author Perez, Montserrat author Martinez, Rafael author de Paz, Raquel author Granell, Miguel author de Arriba, Felipe author Blanchard, M Jesus author Penalver, Francisco-Javier author Bello, Jose Luis author Martin, Maria Luisa author Bargay Lleonart, Joan author Blade, Joan author Lahuerta, Juan Jose author San Miguel, Jesus F author de la Rubia Comos, Javier author 2015 We report the characteristics of relapse, treatment response, and outcomes of 145 elderly patients with multiple myeloma in first relapse after front-line treatment with VMP or VTP. Reappearance of CRAB symptoms (113 patients) and more aggressive forms of disease (32 patients) were the most common patterns of relapse. After second-line therapy, 75 (51.7%) patients achieved at partial response and 16 (11%) complete response (CR). Overall survival was longer among patients receiving VMP as front-line induction (21.4 vs. 14.4 months, P=0.037), in patients achieving CR (28.3 vs. 14.8 months; P=0.04), and in patients without aggressive relapse (28.6 vs. 7.6 months; P=0.0007). Lopez A, Mateos MV, Oriol A, Valero M, Martinez J, Lorenzo JI, et al. Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations.. Leuk Res Rep. 2015;4(2):64-9. 10.1016/j.lrr.2015.09.002 2213-0489 Leukemia Research Reports http://hdl.handle.net/20.500.13003/17426 26500850 L606143667 2-s2.0-84942514302 http://hdl.handle.net/20.500.12105/20083 Elderly patients Patterns of relapse Relapsed myeloma Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations.