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oai:repisalud.isciii.es:20.500.12105/200792024-11-29T03:21:27Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Grases, Felix author Prieto, Rafel M. author Fernandez-Cabot, Rafel A. author Costa-Bauza, Antonia author Tur, Fernando author Juan Torres-Rovira, Jose author 2015 Nephrolithiasis is a complex disease that results from a combination of factors related to both urine composition and kidney morphoanatomy. Development of calcium oxalate monohydrate papillary calculi is linked to initial subepithelial calcification of renal papilla. Progressive tissue calcification depends on preexisting injury and involves reactive oxygen species. Many plant extracts that protect against oxidative stressmanifest antilithiasic activity. Our study focused on determining the effects of polyphenols on a lithiasis rat model. Rats were pretreated with polyphenols and grape seed extracts, followed by posterior induction of hyperoxalosis via treatment with ethylene glycol plus NH4Cl. The concentrations of calcium and other elements in kidney were determined, along with histological examination of kidney and 24 h urine analysis. Significant differences were observed in the renal calcium content between the control plus ethylene glycol-treated group and the epicatechin plus ethylene glycol-treated, red grape seed extract plus ethylene glycol-treated, and white grape seed extract plus ethylene glycol-treated groups, with reductions of about 50%. The antioxidant activity of polyphenols extracted from red and white grape seeds may be critical in the prevention of calcium oxalate monohydrate papillary calculus formation, particularly if calculi are induced by lesions caused by cytotoxic compounds with oxidative capacity. Grases F, Prieto RM, Fernandez-Cabot RA, Costa-Bauza A, Tur F, Juan Torres J. Effects of Polyphenols from Grape Seeds on Renal Lithiasis. Oxidative Med Cell Longev. 2015;2015:813737. Epub 2015 Mar 25. 10.1155/2015/813737 1942-0994 1942-0900 Oxidative Medicine and Cellular Longevity http://hdl.handle.net/20.500.13003/10994 25883748 L603605510 2-s2.0-84927153602 http://hdl.handle.net/20.500.12105/20079 353489700001 Effects of Polyphenols from Grape Seeds on Renal Lithiasis