2026-05-08T19:57:32Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/200542024-09-27T08:43:43Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Gonzalez-Lopez, Esther
author
McPhail, Ellen D
author
Salas-Anton, Clara
author
Dominguez, Fernando
author
Gertz, Morie A
author
Dispenzieri, Angela
author
Dasari, Surendra
author
Milani, Paolo
author
Verga, Laura
author
Grogan, Martha
author
Palladini, Giovanni
author
Garcia-Pavia, Pablo
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia e Innovación (España)
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2024-07-04T10:29:02Z
2024-07-04T10:29:02Z
2024-03-19
J Am Coll Cardiol. 2024 Mar 19;83(11):1085-1099.
10.1016/j.jacc.2024.01.010
1558-3597
Journal of the American College of Cardiology
38479957
http://hdl.handle.net/20.500.12105/20054
Cardiac amyloidosis is increasingly recognized as a treatable form of heart failure. Highly effective specific therapies have recently become available for the 2 most frequent forms of cardiac amyloidosis: immunoglobulin light chain amyloidosis and transthyretin (ATTR) amyloidosis. Nevertheless, initiation of specific therapies requires recognition of cardiac amyloidosis and appropriate characterization of the amyloid type. Although noninvasive diagnosis is possible for ATTR cardiac amyloidosis, histological demonstration and typing of amyloid deposits is still required for a substantial number of patients with ATTR and in all patients with light chain amyloidosis and other rarer forms of cardiac amyloidosis. Amyloid histological typing can be performed using different techniques: mass spectrometry, immunohistochemistry, and immunoelectron microscopy. This review describes which patients require histological confirmation of cardiac amyloidosis along with when and how to type amyloid deposits in histologic specimens. Furthermore, it covers the characteristics and limitations of the different typing methods that are available in clinical practice.
eng
Histological Typing in Patients With Cardiac Amyloidosis: JACC Review Topic of the Week.
review article
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Histological Typing in Patients With Cardiac_J Am Coll Cardiol_2024.pdf
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Histological Typing in Patients With Cardiac_J Am Coll Cardiol_2024.pdf.txt