2026-06-14T03:18:12Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/200372025-03-26T11:52:35Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Fondevila, Marcos F
author
Novoa, Eva
author
Gonzalez-Rellan, Maria J
author
Fernandez, Uxia
author
Heras, Violeta
author
Porteiro, Begoña
author
Parracho, Tamara
author
Dorta, Valentina
author
Riobello, Cristina
author
da Silva Lima, Natalia
author
Seoane, Samuel
author
Garcia-Vence, Maria
author
Chantada-Vazquez, Maria P
author
Bravo, Susana-Belén
author
Senra, Ana
author
Leiva, Magdalena
author
Marcos, Miguel
author
Sabio, Guadalupe
author
Perez-Fernandez, Roman
author
Dieguez, Carlos
author
Prevot, Vincent
author
Schwaninger, Markus
author
Woodhoo, Ashwin
author
Martinez-Chantar, Maria L
author
Schwabe, Robert
author
Cubero, Francisco J
author
Varela-Rey, Marta
author
Crespo, Javier
author
Iruzubieta, Paula
author
Nogueiras, Ruben
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Agencia Estatal de Investigación (España)
funder
Xunta de Galicia (España)
funder
Fundación BBVA
funder
European Foundation for the Study of Diabetes
funder
Unión Europea. Comisión Europea. H2020
funder
Centro de Investigación Biomédica en Red - CIBEROBN (Fisiopatología de la Obesidad y Nutrición)
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2024-07-03T14:55:31Z
2024-07-03T14:55:31Z
2024-02-20
Cell Rep Med. 2024 Feb 20;5(2):101401.
10.1016/j.xcrm.2024.101401
2666-3791
Cell reports. Medicine
38340725
http://hdl.handle.net/20.500.12105/20037
The p63 protein has pleiotropic functions and, in the liver, participates in the progression of nonalcoholic fatty liver disease (NAFLD). However, its functions in hepatic stellate cells (HSCs) have not yet been explored. TAp63 is induced in HSCs from animal models and patients with liver fibrosis and its levels positively correlate with NAFLD activity score and fibrosis stage. In mice, genetic depletion of TAp63 in HSCs reduces the diet-induced liver fibrosis. In vitro silencing of p63 blunts TGF-β1-induced HSCs activation by reducing mitochondrial respiration and glycolysis, as well as decreasing acetyl CoA carboxylase 1 (ACC1). Ectopic expression of TAp63 induces the activation of HSCs and increases the expression and activity of ACC1 by promoting the transcriptional activity of HER2. Genetic inhibition of both HER2 and ACC1 blunt TAp63-induced activation of HSCs. Thus, TAp63 induces HSC activation by stimulating the HER2-ACC1 axis and participates in the development of liver fibrosis.
eng
p63 controls metabolic activation of hepatic stellate cells and fibrosis via an HER2-ACC1 pathway.
research article
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p63 controls metabolic activation_Cell Rep Med_2024.pdf
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https://repisalud.isciii.es/bitstreams/0f7f7d19-558b-4ad4-83fc-81758c141fb3/download
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text/plain
p63 controls metabolic activation_Cell Rep Med_2024.pdf.txt