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oai:repisalud.isciii.es:20.500.12105/200142024-11-28T22:29:34Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud author Flores-Mateo, Gemma author Elosua, Roberto author Rodriguez-Blanco, Teresa author Basora-Gallisa, Josep author Bullo, Monica author Salas-Salvado, Jordi author Angel Martinez-Gonzalez, Miguel author Estruch, Ramon author Corella, Dolores author Fito, Montserrat author Fiol Sala, MiquelAutor/a del sistema sanitario público de las Islas Baleares Orcid author Aros, Fernando author Gomez-Gracia, Enrique author Subirana, Isaac author Lapetra, Jose author Ruiz-Gutierrez, Valentina author Saez, Guillermo T. author Covas, Maria-Isabel author PREDIMED Study Investigators 2024-07-03T11:09:34Z 2024-07-03T11:09:34Z 2014-09-30 Flores-Mateo G, Elosua R, Rodriguez-Blanco T, Basora-Gallisa J, Bullo M, Salas-Salvado J, et al. Oxidative Stress Is Associated with an Increased Antioxidant Defense in Elderly Subjects: A Multilevel Approach. PLoS One. 2014 Sep 30;9(9):e105881. 10.1371/journal.pone.0105881 1932-6203 PloS One http://hdl.handle.net/20.500.13003/11120 25269026 L600086513 2-s2.0-84907482535 http://hdl.handle.net/20.500.12105/20014 343671700007 Background: Studies of associations between plasma GSH-Px activity and cardiovascular risk factors have been done in humans, and contradictory results have been reported. The aim of our study was to assess the association between the scavenger antioxidant enzyme glutathione peroxidase (GSH-Px) activity in plasma and the presence of novel and classical cardiovascular risk factors in elderly patients. Methods: We performed a cross-sectional study with baseline data from a subsample of the PREDIMED (PREvencion con DIeta MEDiterranea) study in Spain. Participants were 1,060 asymptomatic subjects at high risk for cardiovascular disease (CVD), aged 55 to 80, selected from 8 primary health care centers (PHCCs). We assessed classical CVD risk factors, plasma oxidized low-density lipoproteins (ox-LDL), and glutathione peroxidase (GSH-Px) using multilevel statistical procedures. Results: Mean GSH-Px value was 612 U/L (SE: 12 U/L), with variation between PHCCs ranging from 549 to 674 U/L (Variance = 1013.5; P < 0.001). Between-participants variability within a PHCC accounted for 89% of the total variation. Both glucose and oxidized LDL were positively associated with GSH-Px activity after adjustment for possible confounder variables (P = 0.03 and P = 0.01, respectively). Conclusion: In a population at high cardiovascular risk, a positive linear association was observed between plasma GSH-Px activity and both glucose and ox-LDL levels. The high GSH-Px activity observed when an oxidative stress situation occurred, such as hyperglycemia and lipid oxidative damage, could be interpreted as a healthy defensive response against oxidative injury in our cardiovascular risk population. eng Oxidative Stress Is Associated with an Increased Antioxidant Defense in Elderly Subjects: A Multilevel Approach research article