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oai:repisalud.isciii.es:20.500.12105/200122024-11-28T19:39:16Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Castro-Quezada, Itandehui author Sanchez-Villegas, Almudena author Estruch, Ramon author Salas-Salvado, Jordi author Corella, Dolores author Schroeder, Helmut author Alvarez-Perez, Jacqueline author Dolores Ruiz-Lopez, Maria author Artacho, Reyes author Ros, Emilio author Bullo, Monica author Covas, Maria-Isabel author Ruiz-Gutierrez, Valentina author Ruiz-Canela, Miguel author Buil-Cosiales, Pilar author Gomez-Gracia, Enrique author Lapetra, Jose author Pinto, Xavier author Aros, Fernando author Fiol Sala, MiquelAutor/a del sistema sanitario público de las Islas Baleares Orcid author Maria Lamuela-Raventos, Rosa author Angel Martinez-Gonzalez, Miguel author Serra-Majem, Lluis author PREDIMED Study Investigators author 2014-09-24 Objective: Different types of carbohydrates have diverse glycemic response, thus glycemic index (GI) and glycemic load (GL) are used to assess this variation. The impact of dietary GI and GL in all-cause mortality is unknown. The objective of this study was to estimate the association between dietary GI and GL and risk of all-cause mortality in the PREDIMED study. Material and Methods: The PREDIMED study is a randomized nutritional intervention trial for primary cardiovascular prevention based on community-dwelling men and women at high risk of cardiovascular disease. Dietary information was collected at baseline and yearly using a validated 137-item food frequency questionnaire (FFQ). We assigned GI values of each item by a 5-step methodology, using the International Tables of GI and GL Values. Deaths were ascertained through contact with families and general practitioners, review of medical records and consultation of the National Death Index. Cox regression models were used to estimate multivariable-adjusted hazard ratios (HR) and their 95% CI for mortality, according to quartiles of energy-adjusted dietary GI/GL. To assess repeated measures of exposure, we updated GI and GL intakes from the yearly FFQs and used Cox models with time-dependent exposures. Results: We followed 3,583 non-diabetic subjects (4.7 years of follow-up, 123 deaths). As compared to participants in the lowest quartile of baseline dietary GI, those in the highest quartile showed an increased risk of all-cause mortality [HR = 2.15 (95% CI: 1.15-4.04); P for trend = 0.012]. In the repeated-measures analyses using as exposure the yearly updated information on GI, we observed a similar association. Dietary GL was associated with all-causemortality only when subjects were younger than 75 years. Conclusions: High dietary GI was positively associated with all-cause mortality in elderly population at high cardiovascular risk. Castro-Quezada I, Sanchez-Villegas A, Estruch R, Salas-Salvado J, Corella D, Schroeder H, et al. A High Dietary Glycemic Index Increases Total Mortality in a Mediterranean Population at High Cardiovascular Risk. PLoS One. 2014 Sep 24;9(9):e107968. 10.1371/journal.pone.0107968 1932-6203 PloS One http://hdl.handle.net/20.500.13003/11123 25250626 L600068008 2-s2.0-84907452298 http://hdl.handle.net/20.500.12105/20012 342492700064 A High Dietary Glycemic Index Increases Total Mortality in a Mediterranean Population at High Cardiovascular Risk