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00925njm 22002777a 4500 dc Voort, Agnes M. M. Sonnenschein-van der author Arends, Lidia R. author de Jongste, Johan C. author Annesi-Maesano, Isabella author Arshad, S. Hasan author Barros, Henrique author Basterrechea, Mikel author Bisgaard, Hans author Chatzi, Leda author Corpeleijn, Eva author Correia, Sofia author Craig, Leone C. author Devereux, Graham author Dogaru, Cristian author Dostal, Miroslav author Duchen, Karel author Eggesbo, Merete author van der Ent, C. Kors author Fantini, Maria Pia author Forastiere, Francesco author Frey, Urs author Gehring, Ulrike author Gori, Davide author van der Gugten, Anne C author Hanke, Wojciech author Henderson, Alexander J author Heude, Barbara author Iniguez, Carmen author Inskip, Hazel M author Keil, Thomas author Kelleher, Cecily C author Kogevinas, Manolis author Kreiner-Moller, Eskil author Kuehni, Claudia E author Kuepers, Leanne K. author Lancz, Kinga author Larsen, Pernille S author Lau, Susanne author Ludvigsson, Johnny author Mommers, Monique author Andersen, Anne-Marie Nybo author Palkovicova, Lubica author Pike, Katharine C author Pizzi, Costanza author Polanska, Kinga author Porta, Daniela author Richiardi, Lorenzo author Roberts, Graham author Schmidt, Anne author Sram, Radim J. author Sunyer, Jordi author Thijs, Carel author Torrent Quetglas, Maties author Viljoen, Karien author Wijga, Alet H author Vrijheid, Martine author Jaddoe, Vincent W. V. author Duijts, Liesbeth author 2014-05 Background: Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results. Objectives: We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years). Methods: First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age < 37 weeks) and low birth weight (< 2500 g) with childhood asthma outcomes. Results: Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P <. 05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27). Conclusion: Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weight with childhood asthma were largely explained by gestational age at birth. Sonnenschein-Van DerVoort AMM, Arends LR, De Jongste JC, Annesi-Maesano I, Arshad SH, Barros H, et al. Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children. J Allergy Clin Immunol. 2014 May;133(5):1317-29. Epub 2014 Feb 12. 10.1016/j.jaci.2013.12.1082 1097-6825 0091-6749 Journal of Allergy and Clinical Immunology http://hdl.handle.net/20.500.13003/11267 24529685 L53001578 2-s2.0-84899645523 http://hdl.handle.net/20.500.12105/19984 335450700012 Gestational age Low birth weight|Linfant growth Wheezing Asthma Children cohort studies Epidemiology Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children