2026-06-14T06:44:37Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/199752024-11-28T21:30:36Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud author Frank, Matthias Johannes author Walter, Martin S author Rubert, Marina author Thiede, Bernd author Monjo, Marta author Reseland, Janne E. author Haugen, Havard Jostein author Lyngstadaas, Stale Petter 2024-07-03T11:01:26Z 2024-07-03T11:01:26Z 2014-03 Frank MJ, Walter Martin S, Rubert M, Thiede B, Monjo M, Reseland JE, et al. Cathodic Polarization Coats Titanium Based Implant Materials with Enamel Matrix Derivate (EMD). Materials. 2014 Mar;7(3):2210-28. 10.3390/ma7032210 1996-1944 Materials http://hdl.handle.net/20.500.13003/11313 28788564 2-s2.0-84897051621 http://hdl.handle.net/20.500.12105/19975 336089500040 The idea of a bioactive surface coating that enhances bone healing and bone growth is a strong focus of on-going research for bone implant materials. Enamel matrix derivate (EMD) is well documented to support bone regeneration and activates growth of mesenchymal tissues. Thus, it is a prime candidate for coating of existing implant surfaces. The aim of this study was to show that cathodic polarization can be used for coating commercially available implant surfaces with an immobilized but functional and bio-available surface layer of EMD. After coating, XPS revealed EMD-related bindings on the surface while SIMS showed incorporation of EMD into the surface. The hydride layer of the original surface could be activated for coating in an integrated one-step process that did not require any pre-treatment of the surface. SEM images showed nano-spheres and nano-rods on coated surfaces that were EMD-related. Moreover, the surface roughness remained unchanged after coating, as it was shown by optical profilometry. The mass peaks observed in the matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy (MALDI-TOF MS) analysis confirmed the integrity of EMD after coating. Assessment of the bioavailability suggested that the modified surfaces were active for osteoblast like MC3M3-E1 cells in showing enhanced Coll-1 gene expression and ALP activity. eng Bioactive coating Coating technique Enamel matrix derivate EMD Titanium titanium-zirconium Surface modification Cathodic Polarization Coats Titanium Based Implant Materials with Enamel Matrix Derivate (EMD) research article