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00925njm 22002777a 4500 dc Casanova, Ciro author Marin, Jose M author Martinez-Gonzalez, Cristina author de Lucas, Pilar author Mir-Viladrich, Isabel author García-Cosío, Borja author Peces-Barba, German author Calle-Rubio, Miryam author Solanes-Garcia, Ingrid author Agueero, Ramn author de Diego-Damia, Alfredo author Feu-Collado, Nuria author Alfageme, Inmaculada author Irigaray, Rosa author Balcells, Eva author Llunell, Antonia author Bautista Galdiz, Juan author Marin, Margarita author Soler-Cataluna, Juan Jose author Lopez-Campos, Jose Luis author Soriano, Joan B author de-Torres, Juan P author COPD Hist Assessment SpaiN CHAIN C author 2014-01-13 Rationale: Little is known about the longitudinal changes associated with using the 2013 update of the multidimensional GOLD strategy for chronic obstructive pulmonary disease (COPD). Objective: To determine the COPD patient distribution of the new GOLD proposal and evaluate how this classification changes over one year compared with the previous GOLD staging based on spirometry only. Methods: We analyzed data from the CHAIN study, a multicenter observational Spanish cohort of COPD patients who are monitored annually. Categories were defined according to the proposed GOLD: FEV1%, mMRC dyspnea, COPD Assessment Test (CAT), Clinical COPD Questionnaire (CCQ), and exacerbations-hospitalizations. One-year follow-up information was available for all variables except CCQ data. Results: At baseline, 828 stable COPD patients were evaluated. On the basis of mMRC dyspnea versus CAT, the patients were distributed as follows: 38.2% vs. 27.2% in group A, 17.6% vs. 28.3% in group B, 15.8% vs. 12.9% in group C, and 28.4% vs. 31.6% in group D. Information was available for 526 patients at one year: 64.2% of patients remained in the same group but groups C and D show different degrees of variability. The annual progression by group was mainly associated with one-year changes in CAT scores (RR, 1.138; 95% CI: 1.074-1.206) and BODE index values (RR, 2.012; 95% CI: 1.487-2.722). Conclusions: In the new GOLD grading classification, the type of tool used to determine the level of symptoms can substantially alter the group assignment. A change in category after one year was associated with longitudinal changes in the CAT and BODE index. Casanova C, Marin JM, Martinez-Gonzalez C, De Lucas-Ramos P, Mir-Viladrich I, Cosio BG, et al. New GOLD classification: longitudinal data on group assignment. Respir Res. 2014 Jan 13;15:3. 10.1186/1465-9921-15-3 1465-993X Respiratory Research http://hdl.handle.net/20.500.13003/11364 24417879 L52965160 2-s2.0-84892388827 http://hdl.handle.net/20.500.12105/19963 332874300001 COPD GOLD Longitudinal New GOLD classification: longitudinal data on group assignment