2026-05-17T05:57:51Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/199512024-11-29T00:07:44Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Leiva Rus, Alfonso author Aguilo, Antoni author Fajo-Pascual, Marta author Moreno, Lucia author Martin, Ma Carmen author Garcia, Elena Marina author Duro Robles, Rosa Elena author D'Agosto Forteza, Pilar author Iglesias-Iglesias, Ana Aurelia author Company, Rosa Maria author Yañez, Aina M author Llobera Cànaves, Joan author 2014 Background: Lowering blood pressure (BP) by antihypertensive (AHT) drugs reduces the risks of cardiovascular events, stroke, and total mortality. However, poor adherence to AHT medications reduces their effectiveness and increases the risk of adverse events. Objective: To evaluate the effectiveness of a multifactorial adherence-based intervention in a primary care setting in lowering BP. Methods/design: Multicenter parallel randomized controlled trial. Thirty two nurses in 28 primary care centers of three Spanish regions. Patients aged 18-80 years, taking AHT drugs with uncontrolled BP (n=221) were randomized to a control group (usual care) or a multifactorial adherence-based intervention including nurse-led motivational interviews, pill reminders, family support, BP self-recording, and simplification of the dosing regimen by a pharmacist. Main outcome measures: The primary outcome was 12-month blinded measure of systolic BP (mean of three measurements). The secondary outcomes were 12-month diastolic BP and proportion of patients with adequately controlled BP. Results: One hundred and fourteen patients were allocated to the intervention group and 109 to the control group. At 12 months, 212 (89%) participants completed the study. The systolic BP in the intervention group was 151.3 versus 153.7 in the control group (P=0.294). The diastolic BP did not differ between groups (83.4 versus 83.6). Of the patients in the control group, 9.2% achieved BP control versus a 15.8% in the intervention group. The relative risk for achieving BP control was 1.72 (95% confidence interval: 0.83-3.56). Conclusion: A multifactorial intervention based on improving adherence in patients with uncontrolled hypertension failed to find evidence of effectiveness in lowering systolic BP. Leiva A, Aguilo A, Fajo-Pascual M, Moreno L, Martin MC, Garcia EM, et al. Efficacy of a brief multifactorial adherence-based intervention in reducing blood pressure: a randomized clinical trial. Patient Prefer Adherence. 2014;8:1683-90. 10.2147/PPA.S66927 1177-889X Patient Preference and Adherence http://hdl.handle.net/20.500.13003/17193 25525344 L600739571 2-s2.0-84916934673 http://hdl.handle.net/20.500.12105/19951 346118200001 Hypertension medication adherence Blood pressure Intervention studies Efficacy of a brief multifactorial adherence-based intervention in reducing blood pressure: a randomized clinical trial