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oai:repisalud.isciii.es:20.500.12105/199482024-11-28T20:43:05Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Montoya, Alonso author Hervas, Amaia author Fuentes, Joaquin author Cardo-Jalon, Esther author Polavieja, Pepa author Quintero, Javier author Tannock, Rosemary author 2014 Background: This multicenter, cluster-randomized, nonblinded study evaluated the effect of parental psychoeducation on medication persistence among children and adolescents with newly diagnosed attention-deficit/hyperactivity disorder (ADHD). Methods: Patients received standard medication alone or medication plus a parental psychoeducation program, and were followed for 12 months. The primary endpoint was time to withdrawal or termination of medication due to any cause. Secondary endpoints included change in ADHD symptom severity, functional outcome, program satisfaction, and safety. Results: A total of 208 patients completed the study, which was terminated early because recruitment had ceased. At 12 months, there was no significant difference between the psychoeducation and control groups in the proportion of patients who discontinued pharmacologic treatment (13.2% versus 14.3%, respectively; size effect -0.3, P=0.34; hazard ratio 0.72, 95% confidence interval 0.36-1.43). Psychoeducation was associated with a significantly greater improvement in ADHD symptoms but not in functional outcome. Parental satisfaction with psychoeducation was high, and satisfaction with pharmacologic treatment was significantly greater in the psychoeducation group. There were no safety concerns. Conclusion: No significant advantage for parental psychoeducation plus medication over medication alone in terms of time to medication withdrawal was observed. Psychoeducation had inconsistent but interesting effects on other outcomes. Montoya A, Hervas A, Fuentes J, Cardo Jalon E, Polavieja P, Quintero J, et al. Cluster-randomized, controlled 12-month trial to evaluate the effect of a parental psychoeducation program on medication persistence in children with attention-deficit/hyperactivity disorder. Neuropsychiatr Dis Treat. 2014;10:1081-92. 10.2147/NDT.S62487 1178-2021 Neuropsychiatric Disease and Treatment http://hdl.handle.net/20.500.13003/17332 24966679 L373339437 2-s2.0-84902573455 http://hdl.handle.net/20.500.12105/19948 338423300005 Psychoeducation Medication persistence Attention-deficit/hyperactivity disorder Adjunctive psychoeducation Parents Cluster-randomized, controlled 12-month trial to evaluate the effect of a parental psychoeducation program on medication persistence in children with attention-deficit/hyperactivity disorder