2026-07-08T02:10:41Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/199282024-09-27T09:31:38Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Restrepo-Córdoba, María Alejandra author Chmielewski, Przemyslaw author Truszkowska, Grażyna author Peña-Peña, María Luisa author Kubánek, Miloš author Krebsová, Alice author Lopes, Luis R author García-Ropero, Álvaro author Merlo, Marco author Paldino, Alessia author Peters, Stacey author Jurcut, Ruxandra author Barriales-Villa, Roberto author Zorio, Esther author Hazebroek, Mark author Mogensen, Jens author Garcia-Pavia, Pablo author 2024-04-18 INTRODUCTION AND OBJECTIVES Limited information is available on the safety of pregnancy in patients with genetic dilated cardiomyopathy (DCM) and in carriers of DCM-causing genetic variants without the DCM phenotype. We assessed cardiac, obstetric, and fetal or neonatal outcomes in this group of patients. METHODS We studied 48 women carrying pathogenic or likely pathogenic DCM-associated variants (30 with DCM and 18 without DCM) who had 83 pregnancies. Adverse cardiac events were defined as heart failure (HF), sustained ventricular tachycardia, ventricular assist device implantation, heart transplant, and/or maternal cardiac death during pregnancy, or labor and delivery, and up to the sixth postpartum month. RESULTS A total of 15 patients, all with DCM (31% of the total cohort and 50% of women with DCM) experienced adverse cardiac events. Obstetric and fetal or neonatal complications were observed in 14% of pregnancies (10 in DCM patients and 2 in genetic carriers). We analyzed the 30 women who had been evaluated before their first pregnancy (12 with overt DCM and 18 without the phenotype). Five of the 12 (42%) women with DCM had adverse cardiac events despite showing NYHA class I or II before pregnancy. Most of these women had a history of cardiac events before pregnancy (80%). Among the 18 women without phenotype, 3 (17%) developed DCM toward the end of pregnancy. CONCLUSIONS Cardiac complications during pregnancy and postpartum were common in patients with genetic DCM and were primarily related to HF. Despite apparently good tolerance of pregnancy in unaffected genetic carriers, pregnancy may act as a trigger for DCM onset in a subset of these women. Rev Esp Cardiol. 2024 Apr 18:S1885-5857(24)00128-2. 10.1016/j.rec.2024.04.002 1885-5857 Revista espanola de cardiologia (English ed.) 38641168 http://hdl.handle.net/20.500.12105/19928 Pregnancy in women with dilated cardiomyopathy genetic variants.