2026-06-14T03:53:09Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/199202024-09-27T22:39:37Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Lopez, Daniel
author
García-Peydró, Marina
funder
Ministerio de Ciencia e Innovación (España)
2024-07-03T06:40:26Z
2024-07-03T06:40:26Z
2024-01
Biomedicines. 2024;12(1):62.
10.3390/biomedicines12010062
2227-9059
Biomedicines
38255169
http://hdl.handle.net/20.500.12105/19920
SARS-CoV-2 caused the devastating COVID-19 pandemic, which, to date, has resulted in more than 800 million confirmed cases and 7 million deaths worldwide. The rapid development and distribution (at least in high-income countries) of various vaccines prevented these overwhelming numbers of infections and deaths from being much higher. But would it have been possible to develop a prophylaxis against this pandemic more quickly? Since SARS-CoV-2 belongs to the subgenus sarbecovirus, with its highly homologous SARS-CoV-1, we propose here that while SARS-CoV-2-specific vaccines are being developed, phase II clinical trials of specific SARS-CoV-1 vaccines, which have been in the pipeline since the early 20th century, could have been conducted to test a highly probable cross-protection between SARS-CoV-1 and SARS-CoV-2.
eng
HLA
Vaccines
Cross-reactivity
T cells
SARS-CoV-2
Could SARS-CoV-1 Vaccines in the Pipeline Have Contributed to Fighting the COVID-19 Pandemic? Lessons for the Next Coronavirus Plague
research article
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URL
https://repisalud.isciii.es/bitstreams/99c4d034-b711-4e9b-9fdc-f0c22f6a984e/download
File
MD5
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application/pdf
Could_SARS-CoV-1_Vaccines_2024.pdf
URL
https://repisalud.isciii.es/bitstreams/075c88c0-2f11-49ab-88e4-0ff923c19367/download
File
MD5
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text/plain
Could_SARS-CoV-1_Vaccines_2024.pdf.txt