2026-04-29T19:35:01Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/199182024-09-27T07:55:35Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Palomo, Iván author Wehinger, Sergio author Andres, Vicente author García-García, Francisco J author Fuentes, Eduardo author 2024-04 The small GTPase RhoA and the downstream Rho kinase (ROCK) regulate several cell functions and pathological processes in the vascular system that contribute to the age-dependent risk of cardiovascular disease, including endothelial dysfunction, excessive permeability, inflammation, impaired angiogenesis, abnormal vasoconstriction, decreased nitric oxide production and apoptosis. Frailty is a loss of physiological reserve and adaptive capacity with advanced age and is accompanied by a pro-inflammatory and pro-oxidative state that promotes vascular dysfunction and thrombosis. This review summarises the role of the RhoA/Rho kinase signalling pathway in endothelial dysfunction, the acquisition of the pro-thrombotic state and vascular ageing. We also discuss the possible role of RhoA/Rho kinase signalling as a promising therapeutic target for the prevention and treatment of age-related cardiovascular disease. J Cell Mol Med. 2024 Apr;28(8):e18153. 10.1111/jcmm.18153 1582-4934 Journal of cellular and molecular medicine 38568071 http://hdl.handle.net/20.500.12105/19918 RhoA/rho kinase pathway activation in age-associated endothelial cell dysfunction and thrombosis.