2026-05-31T00:47:38Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/199162024-09-27T09:12:55Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Swanton, Charles
author
Bernard, Elsa
author
Abbosh, Chris
author
André, Fabrice
author
Auwerx, Johan
author
Balmain, Allan
author
Bar-Sagi, Dafna
author
Bernards, René
author
Bullman, Susan
author
DeGregori, James
author
Elliott, Catherine
author
Erez, Ayelet
author
Evan, Gerard
author
Febbraio, Mark A
author
Hidalgo, Andres
author
Jamal-Hanjani, Mariam
author
Joyce, Johanna A
author
Kaiser, Matthew
author
Lamia, Katja
author
Locasale, Jason W
author
Loi, Sherene
author
Malanchi, Ilaria
author
Merad, Miriam
author
Musgrave, Kathryn
author
Patel, Ketan J
author
Quezada, Sergio
author
Wargo, Jennifer A
author
Weeraratna, Ashani
author
White, Eileen
author
Winkler, Frank
author
Wood, John N
author
Vousden, Karen H
author
Hanahan, Douglas
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Swiss National Science Foundation
funder
NIH - National Cancer Institute (NCI) (Estados Unidos)
2024-07-02T14:25:41Z
2024-07-02T14:25:41Z
2024-03-28
Cell. 2024 Mar 28;187(7):1589-1616.
10.1016/j.cell.2024.02.009
1097-4172
Cell
38552609
http://hdl.handle.net/20.500.12105/19916
The last 50 years have witnessed extraordinary developments in understanding mechanisms of carcinogenesis, synthesized as the hallmarks of cancer. Despite this logical framework, our understanding of the molecular basis of systemic manifestations and the underlying causes of cancer-related death remains incomplete. Looking forward, elucidating how tumors interact with distant organs and how multifaceted environmental and physiological parameters impinge on tumors and their hosts will be crucial for advances in preventing and more effectively treating human cancers. In this perspective, we discuss complexities of cancer as a systemic disease, including tumor initiation and promotion, tumor micro- and immune macro-environments, aging, metabolism and obesity, cancer cachexia, circadian rhythms, nervous system interactions, tumor-related thrombosis, and the microbiome. Model systems incorporating human genetic variation will be essential to decipher the mechanistic basis of these phenomena and unravel gene-environment interactions, providing a modern synthesis of molecular oncology that is primed to prevent cancers and improve patient quality of life and cancer outcomes.
eng
Embracing cancer complexity: Hallmarks of systemic disease.
journal article
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Embracing cancer complexity_Cell_2024.pdf
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https://repisalud.isciii.es/bitstreams/8a4f0f20-9ce6-4cf2-9efd-bc30ef6eb049/download
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Embracing cancer complexity_Cell_2024.pdf.txt