2026-05-31T00:47:37Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/199162024-09-27T09:12:55Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Swanton, Charles author Bernard, Elsa author Abbosh, Chris author André, Fabrice author Auwerx, Johan author Balmain, Allan author Bar-Sagi, Dafna author Bernards, René author Bullman, Susan author DeGregori, James author Elliott, Catherine author Erez, Ayelet author Evan, Gerard author Febbraio, Mark A author Hidalgo, Andres author Jamal-Hanjani, Mariam author Joyce, Johanna A author Kaiser, Matthew author Lamia, Katja author Locasale, Jason W author Loi, Sherene author Malanchi, Ilaria author Merad, Miriam author Musgrave, Kathryn author Patel, Ketan J author Quezada, Sergio author Wargo, Jennifer A author Weeraratna, Ashani author White, Eileen author Winkler, Frank author Wood, John N author Vousden, Karen H author Hanahan, Douglas author 2024-03-28 The last 50 years have witnessed extraordinary developments in understanding mechanisms of carcinogenesis, synthesized as the hallmarks of cancer. Despite this logical framework, our understanding of the molecular basis of systemic manifestations and the underlying causes of cancer-related death remains incomplete. Looking forward, elucidating how tumors interact with distant organs and how multifaceted environmental and physiological parameters impinge on tumors and their hosts will be crucial for advances in preventing and more effectively treating human cancers. In this perspective, we discuss complexities of cancer as a systemic disease, including tumor initiation and promotion, tumor micro- and immune macro-environments, aging, metabolism and obesity, cancer cachexia, circadian rhythms, nervous system interactions, tumor-related thrombosis, and the microbiome. Model systems incorporating human genetic variation will be essential to decipher the mechanistic basis of these phenomena and unravel gene-environment interactions, providing a modern synthesis of molecular oncology that is primed to prevent cancers and improve patient quality of life and cancer outcomes. Cell. 2024 Mar 28;187(7):1589-1616. 10.1016/j.cell.2024.02.009 1097-4172 Cell 38552609 http://hdl.handle.net/20.500.12105/19916 Embracing cancer complexity: Hallmarks of systemic disease.