2026-05-20T22:57:01Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/195282025-02-04T12:45:49Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16938col_20.500.12105_19617
Repisalud
author
Alves, Victoria Cunha
author
Carro, Eva
author
Figueiro-Silva, Joana
2024-05-23T08:32:02Z
2024-05-23T08:32:02Z
2024-11-01
Neural Regen Res. 2024 Nov 1;19(11):2365-2376.
10.4103/1673-5374.393106
1673-5374
Neural regeneration research
38526273
http://hdl.handle.net/20.500.12105/19528
The intricacies of Alzheimer's disease pathogenesis are being increasingly illuminated by the exploration of epigenetic mechanisms, particularly DNA methylation. This review comprehensively surveys recent human-centered studies that investigate whole genome DNA methylation in Alzheimer's disease neuropathology. The examination of various brain regions reveals distinctive DNA methylation patterns that associate with the Braak stage and Alzheimer's disease progression. The entorhinal cortex emerges as a focal point due to its early histological alterations and subsequent impact on downstream regions like the hippocampus. Notably, ANK1 hypermethylation, a protein implicated in neurofibrillary tangle formation, was recurrently identified in the entorhinal cortex. Further, the middle temporal gyrus and prefrontal cortex were shown to exhibit significant hypermethylation of genes like HOXA3, RHBDF2, and MCF2L, potentially influencing neuroinflammatory processes. The complex role of BIN1 in late-onset Alzheimer's disease is underscored by its association with altered methylation patterns. Despite the disparities across studies, these findings highlight the intricate interplay between epigenetic modifications and Alzheimer's disease pathology. Future research efforts should address methodological variations, incorporate diverse cohorts, and consider environmental factors to unravel the nuanced epigenetic landscape underlying Alzheimer's disease progression.
eng
Alzheimer’s disease
ANK1
BIN1
DNA methylation
Epigenome-wide association studies
HOXA3
MCF2L
RHBDF2
Unveiling DNA methylation in Alzheimer's disease: a review of array-based human brain studies
review article
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URL
https://repisalud.isciii.es/bitstreams/df9ebc61-e90a-45bc-b8d2-fc0ce15c3f09/download
File
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application/pdf
UnveilingDNA_MethylationAlzheimersDisease_2024.pdf
URL
https://repisalud.isciii.es/bitstreams/3000dce5-678a-46e5-86ba-080671247afc/download
File
MD5
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text/plain
UnveilingDNA_MethylationAlzheimersDisease_2024.pdf.txt