2026-06-14T02:29:47Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/195202025-05-05T17:17:13Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Perez-Garcia, Felipe author Resino, Salvador author Gómez-Sánchez, Esther author Gonzalo-Benito, Hugo author Fernandez-Rodriguez, Amanda author Lorenzo-López, Mario author Heredia-Rodríguez, María author Gómez-Pesquera, Estefanía author Tamayo, Eduardo author Jimenez-Sousa, Maria Angeles author Group of Biomedical Research in Critical Care Medicine (BioCritic) author 2021-04 Background: Higher expression of olfactomedin-4 (OLFM4), a gene regulated by nuclear factor-kappa B (NF-κB), has been related to a higher risk of organ failure and death in patients with septic shock. We aimed to evaluate the association between OLFM4 single nucleotide polymorphisms (SNPs) and septic shock-related death in 175 patients who underwent major surgery, as well as its performance in predicting mortality. Materials and methods: We carried out a retrospective study. A total of seven OLFM4 SNPs were genotyped by Agena Bioscience's MassARRAY platform. Statistical analysis was performed by Kaplan-Meier and Cox regression tests. The diagnostic performance for predicting septic shock-related death was evaluated by the area under the receiver-operating characteristic (AUROC) curve. Results: Patients with rs17552047 A allele and rs1891944 TT genotype had higher survival than patients with rs17552047 G allele (P-value = .024) and patients with rs1891944 CC/CT genotype (P-value = .038). However, only rs17552047 was associated with a lower risk of death under an additive inheritance model (adjusted hazard ratio [aHR] = 0.44, 95% CI = 0.27-0.71). The multivariate model with the most significant clinical variables (lactate, chronic kidney disease, peritonitis, heart disease and elective surgery) showed an AUROC of 0.776 for predicting septic shock-related death. When we added the OLFM4 rs17552047 SNP to the previous model, the AUROC was 0.811 and was close to reaching significant differences with the previous model (P-value = .065). Conclusion: OLFM4 rs17552047 A allele predicts septic shock survival in patients who underwent major surgery. Furthermore, rs17552047, together with clinical variables, could be useful to predict the outcome of septic shock. Eur J Clin Invest. 2021 Apr;51(4):e13416. 10.1111/eci.13416 1365-2362 European journal of clinical investigation 32996122 http://hdl.handle.net/20.500.12105/19520 Major surgery OLFM4 rs17552047 Septic shock SNPs Survival OLFM4 polymorphisms predict septic shock survival after major surgery