2026-08-29T09:51:29Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/195172024-09-27T19:21:38Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Jimenez-Sousa, Maria Angeles author Gómez-Moreno, Ana Zaida author Pineda-Tenor, Daniel author Sánchez-Ruano, Juan José author Fernandez-Rodriguez, Amanda author Artaza-Varasa, Tomas author Gomez-Sanz, Alicia author Martin-Vicente, Maria author Vázquez-Morón, Sonia author Resino, Salvador author 2018-06 Background: Host genetic background has been associated with liver fibrosis progression. Objective: To analyze the association between the patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 polymorphism and liver fibrosis progression in hepatitis C virus (HCV)-infected patients. Study design: In this retrospective cohort study, 187 patients with chronic HCV infection were included, who had at least two liver stiffness measurements (LSM) by transient elastography during the follow-up. Results were expressed in kilopascals (kPa). The analysis of genetic association was carried out according to additive model by using Generalized Linear Models. Results: No patients had advanced fibrosis/cirrhosis at baseline. During a median follow-up time of 47.9 months, 15 patients developed advanced fibrosis and 17 cirrhosis. In multivariate analysis adjusted by the main clinical and epidemiological covariates, the rs738409 G allele was related to higher increase of LSM values during the follow-up (adjusted arithmetic mean ratio (aAMR) = 1.16 (95%CI = 1.04; 1.29); p = .006) and higher odds of having progression to advanced fibrosis [aOR = 2.03 (95%CI = 1.01; 4.06); p = .045], and progression to cirrhosis [aOR = 3.03 (95%CI = 1.26; 7.30); p = .014]. Conclusions: PNPLA3 rs738409 polymorphism appears to be related to the increased progression of liver fibrosis in HCV infected patients. J Clin Virol. 2018 Jun:103:71-74. 10.1016/j.jcv.2018.04.008 1873-5967 Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 29674183 http://hdl.handle.net/20.500.12105/19517 Chronic hepatitis C Cirrhosis Hepatic fibrosis Liver stiffness PNPLA3 SNPs PNPLA3 rs738409 polymorphism is associated with liver fibrosis progression in patients with chronic hepatitis C: A repeated measures study