2026-05-22T06:19:31Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/195162025-03-19T14:02:08Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16977col_20.500.12105_16978
Repisalud
author
Jimenez-Sousa, Maria Angeles
author
Berenguer, Juan
author
Rallón, Norma
author
Pineda-Tenor, Daniel
author
Aldámiz-Echevarria, Teresa
author
Soriano, Vicente
author
Garcia-Alvarez, Monica
author
Vázquez-Morón, Sonia
author
Restrepo, Clara
author
Carrero, Ana
author
Benito, José M
author
Resino, Salvador
funder
Instituto de Salud Carlos III
funder
RETICS-Sida (RIS-ISCIII) (España)
funder
Plan Nacional de I+D+i (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2024-05-22T08:12:32Z
2024-05-22T08:12:32Z
2016-09
Liver Int. 2016 Sep;36(9):1258-66.
10.1111/liv.13079
1478-3231
Liver international : official journal of the International Association for the Study of the Liver
26836972
http://hdl.handle.net/20.500.12105/19516
Background & aims: IL15 is an essential cytokine in both innate and adaptive immune response against hepatitis C virus (HCV) infection. The aim was to analyze whether IL15 rs10833 is associated with liver disease severity and response to pegylated-interferon-alpha plus ribavirin (pegIFN-alpha/RBV) therapy in human immunodeficiency virus (HIV)-/HCV-co-infected patients. Methods: A retrospective study was performed in 315 patients who started pegIFN-alpha/RBV therapy. Liver fibrosis stage was characterized in 286 patients. IL15 rs10833 and IL28B rs12980275 were genotyped by GoldenGate. The primary outcomes were: (a) advanced liver fibrosis evaluated by liver biopsy (F3-F4) or transient elastography (liver stiffness values ≥9.5 Kpa); (b) sustained virological response (SVR). The secondary outcome variable was the levels of serum biomarkers of inflammation. Results: Patients with rs10833 AA genotype had increased odds of having advanced fibrosis (adjusted odds ratio (aOR) = 2.30; P = 0.019), particularly in males (aOR = 2.24; P = 0.040), patients with HCV serum viral load (HCV-RNA) <500 000 IU/ml (aOR = 5.14; P = 0.018) and patients with IL28B rs12980275 AG/GG genotypes (aOR = 2.51; P = 0.046). Moreover, rs10833 AA genotype was significantly associated with higher levels of hepatocyte growth factor (adjusted arithmetic mean ratio (aAMR) = 1.50; P = 0.016), sICAM-1 (aAMR = 1.57; P = 0.025) and sVCAM-1 (aAMR = 1.56; P = 0.007). Finally, patients with rs10833 AA genotype had increased odds of achieving SVR (aOR = 3.12; P = 0.006), particularly in males (aOR = 3.69; P = 0.005), GT1/4 patients (aOR = 3.59; P = 0.006), patients with advanced fibrosis (aOR = 4.64; P = 0.021), HCV-RNA ≥500 000 IU/ml (aOR = 3.92; P = 0.007) and patients with IL28B rs12980275 AG/GG genotype (aOR = 2.98; P = 0.041). Conclusions: The presence of IL15 rs10833 AA genotype in HIV-/HCV-co-infected patients was associated with advanced liver fibrosis, inflammation-related biomarkers and increased rates of SVR to pegIFN-alpha/RBV therapy.
eng
AIDS
Fbrosis
Hepatitis C virus therapy
Interleukin 15
Single nucleotide polymorphisms
IL15 polymorphism is associated with advanced fibrosis, inflammation-related biomarkers and virological response in human immunodeficiency virus/hepatitis C virus coinfection
research article
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IL15_PolymorphismAssociatedAdvancedFibrosis_2016.pdf
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https://repisalud.isciii.es/bitstreams/cfe7cfb0-b844-4173-a211-8218ad7f9807/download
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IL15_PolymorphismAssociatedAdvancedFibrosis_2016.pdf.txt