2026-06-14T03:37:28Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/195092025-04-03T17:15:51Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16978

00925njm 22002777a 4500 dc Guzman-Fulgencio, Maria author Berenguer, Juan author Jimenez-Sousa, Maria Angeles author Micheloud, Dariela author Garcia-Alvarez, Monica author Bellón, José María author Aldámiz-Echevarria, Teresa author Garcia-Broncano, Pilar author Catalán, Pilar author Díez, Cristina author Pineda-Tenor, Daniel author Resino, Salvador author 2015-11 Background: The IL7RA polymorphisms have recently been associated with CD4+ T-cell decline in untreated HIV-infected subjects and CD4+ T-cell recovery in patients on combination antiretroviral therapy (cART). The aim of this study was to evaluate whether IL7RA polymorphisms are associated with CD4+ T-cell recovery in HIV-infected patients on long-term cART. Study design: We performed a retrospective study in 151 naïve cART patients with severe immunodeficiency (CD4+ counts ≤200 cells/mm(3) ). IL7RA polymorphisms' genotyping was performed using Sequenom's MassARRAY platform. The outcome variable was the time to achieve the first value of CD4+ count ≥500 cells/mm(3) during the follow-up. Results: Two different trends of CD4+ T-cell recovery were found in Kaplan-Meier analysis. During the first 48 months, 60 of 151 (39·7%) of the patients reached CD4+ T-cell values ≥500 cells/mm(3) , and no differences were observed between IL7RA genotypes. After the first 48 months of follow-up, 27 of 151 (17·8%) of the patients reached CD4+ T-cell values ≥500 cells/mm(3) , with a different pattern of CD4+ recovery depending on IL7RA genotype. Patients with rs10491434 TT genotype and rs6897932 TT genotype were more likely of achieving CD4+ value ≥500 cells/mm(3) than patients with rs10491434 CT/CC genotype (adjusted hazard ratio (aHR) = 3·59; P = 0·005) and patients with rs6897932 CC/CT genotype (aHR = 11·7; P < 0·001). Conclusions: The IL7RA polymorphisms seem to be associated with CD4+ T-cell recovery in HIV-infected patients who started cART with severe immunodeficiency, in the second phase of CD4+ T-cell recovery after long-term cART. Eur J Clin Invest. 2015 Nov;45(11):1192-9. 10.1111/eci.12539 1365-2362 European journal of clinical investigation 26402121 http://hdl.handle.net/20.500.12105/19509 AIDS Antiretroviral therapy IL7RA Immune system reconstitution Polymorphisms IL7RA polymorphisms predict the CD4+ recovery in HIV patients on cART