2026-04-29T04:52:15Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/194962024-09-27T20:30:19Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Medrano, Luz Maria
author
Jimenez-Sousa, Maria Angeles
author
Fernandez-Rodriguez, Amanda
author
Resino, Salvador
funder
Instituto de Salud Carlos III
2024-05-21T06:51:23Z
2024-05-21T06:51:23Z
2017
AIDS Rev. 2017 Jan-Mar;19(1):3-15.
http://hdl.handle.net/20.500.12105/19496
28182609
1698-6997
AIDS reviews
The pathogenic mechanisms of the accelerated progression of liver injury in HIV/HCV coinfection are incompletely understood. The progression of liver disease is variable between individuals having similar risk factors, suggesting that genetic background is an important contributor. The aim of this review is to give a summary of all single nucleotide polymorphisms associated with the severity of liver disease in patients coinfected with HIV and HCV reported in the literature. Therefore, a systematic search for articles published was made, 17 of which were selected for this review. In summary, a large number of single nucleotide polymorphisms have been associated with the severity of liver disease in HIV/HCV-coinfected patients. These genes are involved in different biological processes, including seven that correspond to cytokine genes (IFNL3-4, CXCL9-11, IL15, TNF), two to receptor genes (IL7R, TLR8), and three are genes related to metabolism (PNPLA3, FTO, GSTM1). In addition, two combinations of polymorphisms (cirrhosis risk score and mitochondrial haplogroups) have also been related to severity of liver disease in HIV/HCV-coinfected patients. Although determinants other than genetics, such as environmental and viral factors, may be implicated in liver disease progression, information about genetic variation might be useful in clinical practice, allowing prioritization of patients with a genetic background that predispose to a worse evolution of HCV-related liver disease.
eng
Genetic polymorphisms
HCV/HIV coinfection
Liver fibrosis
Cirrhosis
Liver-related disease
Genetic Polymorphisms Associated with Liver Disease Progression in HIV/HCV-Coinfected Patients
review article
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GeneticPolymorphismsAssociatedLiverDisease_2017.pdf
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GeneticPolymorphismsAssociatedLiverDisease_2017.pdf.txt