2026-04-17T15:26:20Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/194452024-09-27T08:14:26Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Muñoz-Hernando, María
author
Nogales, Paula
author
Fernández-Barahona, Irene
author
Ruiz-Cabello, Jesús
author
Bentzon, Jacob F
author
Herranz, Fernando
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia e Innovación (España)
funder
Comunidad de Madrid (España)
funder
Fundación La Caixa
funder
Fundación ProCNIC
2024-05-17T15:09:35Z
2024-05-17T15:09:35Z
2024-03-28
Nanoscale. 2024 Mar 28;16(13):6477-6487.
http://hdl.handle.net/20.500.12105/19445
38426659
10.1039/d3nr06507c
2040-3372
Nanoscale
Atherosclerosis, a leading cause of cardiovascular diseases requires approaches to enhance disease monitoring and treatment. Nanoparticles offer promising potential in this area by being customisable to target components or molecular processes within plaques, while carrying diagnostic and therapeutic agents. However, the number of biomarkers available to target this disease is limited. This study investigated the use of sphingomyelin-based nanomicelles triggered by sphingomyelinase (SMase) in atherosclerotic plaques. Accumulation of iron oxide-based nanomicelles in the plaque was demonstrated by fluorescence, MR imaging and electron microscopy. These findings demonstrate the possibility of utilising SMase as a mechanism to retain nanoprobes within plaques, thus opening up possibilities for future therapeutic interventions.
eng
Sphingomyelinase-responsive nanomicelles for targeting atherosclerosis.
journal article
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URL
https://repisalud.isciii.es/bitstreams/d761d992-2f75-475d-8fe7-e7b55f2b145b/download
File
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application/pdf
Sphingomyelinase_responsive_Nanoscale_2024.pdf
URL
https://repisalud.isciii.es/bitstreams/92e271ba-c258-44ae-bea9-97877ac20291/download
File
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text/plain
Sphingomyelinase_responsive_Nanoscale_2024.pdf.txt