2026-04-29T06:16:09Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/193682024-09-27T09:41:58Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Paternina-Die, María author Martínez-García, Magdalena author Martín de Blas, Daniel author Noguero, Inés author Servin-Barthet, Camila author Pretus, Clara author Soler, Anna author López-Montoya, Gonzalo author Desco, Manuel author Carmona, Susana author 2024-02 Pregnancy is a unique neuroplastic period in adult life. This longitudinal study tracked brain cortical changes during the peripartum period and explored how the type of childbirth affects these changes. We collected neuroanatomic, obstetric and neuropsychological data from 110 first-time mothers during late pregnancy and early postpartum, as well as from 34 nulliparous women evaluated at similar time points. During late pregnancy, mothers showed lower cortical volume than controls across all functional networks. These cortical differences attenuated in the early postpartum session. Default mode and frontoparietal networks showed below-expected volume increases during peripartum, suggesting that their reductions may persist longer. Results also pointed to different cortical trajectories in mothers who delivered by scheduled C-section. The main findings were replicated in an independent sample of 29 mothers and 24 nulliparous women. These data suggest a dynamic trajectory of cortical decreases during pregnancy that attenuates in the postpartum period, at a different rate depending on the brain network and childbirth type. Nat Neurosci. 2024 Feb;27(2):319-327. http://hdl.handle.net/20.500.12105/19368 38182834 10.1038/s41593-023-01513-2 1546-1726 Nature neuroscience Women's neuroplasticity during gestation, childbirth and postpartum.