2026-04-29T00:59:46Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/193582024-09-27T09:51:15Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Arnaldos-Carrillo, María
author
Noguera-Velasco, José Antonio
author
Martínez-Ardil, Isabel M
author
Riquelme-Pérez, Alejandro
author
Cebreiros-López, Iria
author
Hernández-Vicente, Álvaro
author
Ros-Lucas, José Antonio
author
Khan, Amjad
author
Bayes-Genís, Antoni
author
Pascual-Figal, Domingo A
2024-05-10T10:21:34Z
2024-05-10T10:21:34Z
2023-09-08
Med Clin (Barc). 2023 Sep 8;161(5):185-191.
http://hdl.handle.net/20.500.12105/19358
37137804
10.1016/j.medcli.2023.04.005
1578-8989
Medicina clinica
BACKGROUND
Soluble suppressor of tumorigenicity-2 (sST2) is a biomarker for heart failure and pulmonary injury. We hypothesize that sST2 could help predict severity of SARS-CoV-2 infections.
METHODS
sST2 was analyzed in patients consecutively admitted for SARS-CoV-2 pneumonia. Other prognostic markers were also measured. In-hospital complications were registered, including death, ICU admission, and respiratory support requirements.
RESULTS
495 patients were studied (53% male, age: 57.6±17.6). At admission, median sST2 concentrations was 48.5ng/mL [IQR, 30.6-83.1ng/mL] and correlated with male gender, older age, comorbidities, other severity biomarkers, and respiratory support requirements. sST2 levels were higher in patients who died (n=45, 9.1%) (45.6 [28.0, 75.9]ng/mL vs. 144 [82.6, 319] ng/mL, p<0.001) and those admitted to ICU (n=46, 9.3%) (44.7 [27.5, 71.3] ng/mL vs. 125 [69.0, 262]ng/mL, p<0.001). sST2 levels>210ng/mL were a strong predictor of complicated in-hospital courses, with higher risk of death (OR, 39.3, CI95% 15.9, 103) and death/ICU (OR 38.3, CI95% 16.3-97.5) after adjusting for all other risk factors. The addition of sST2 enhanced the predictive capacity of mortality risk models.
CONCLUSIONS
sST2 represents a robust severity predictor in COVID-19 and could be an important tool for identifying at-risk patients who may benefit from closer follow-up and specific therapies.
eng
Value of increased soluble suppressor tumorigenicity biomarker 2 (sST2) on admission as an indicator of severity in patients with COVID-19.
journal article
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Value of increased soluble suppressor_Med Clin_2023.pdf
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Value of increased soluble suppressor_Med Clin_2023.pdf.txt