2026-04-17T18:24:02Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/193342024-05-27T19:32:32Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Maas, Roeltje R author Soukup, Klara author Fournier, Nadine author Massara, Matteo author Galland, Sabine author Kornete, Mara author Wischnewski, Vladimir author Lourenco, Joao author Croci, Davide author Álvarez-Prado, Ángel F author Marie, Damien N author Lilja, Johanna author Marcone, Rachel author Calvo, Gabriel F author Santalla Mendez, Rui author Aubel, Pauline author Bejarano, Leire author Wirapati, Pratyaksha author Ballesteros, Iván author Hidalgo, Andrés author Hottinger, Andreas F author Brouland, Jean-Philippe author Daniel, Roy T author Hegi, Monika E author Joyce, Johanna A author 2023-10-12 Neutrophils are abundant immune cells in the circulation and frequently infiltrate tumors in substantial numbers. However, their precise functions in different cancer types remain incompletely understood, including in the brain microenvironment. We therefore investigated neutrophils in tumor tissue of glioma and brain metastasis patients, with matched peripheral blood, and herein describe the first in-depth analysis of neutrophil phenotypes and functions in these tissues. Orthogonal profiling strategies in humans and mice revealed that brain tumor-associated neutrophils (TANs) differ significantly from blood neutrophils and have a prolonged lifespan and immune-suppressive and pro-angiogenic capacity. TANs exhibit a distinct inflammatory signature, driven by a combination of soluble inflammatory mediators including tumor necrosis factor alpha (TNF-ɑ) and Ceruloplasmin, which is more pronounced in TANs from brain metastasis versus glioma. Myeloid cells, including tumor-associated macrophages, emerge at the core of this network of pro-inflammatory mediators, supporting the concept of a critical myeloid niche regulating overall immune suppression in human brain tumors. Cell. 2023 Oct 12;186(21):4546-4566.e27. http://hdl.handle.net/20.500.12105/19334 37769657 10.1016/j.cell.2023.08.043 1097-4172 Cell The local microenvironment drives activation of neutrophils in human brain tumors.