2026-05-09T10:38:20Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/193302024-09-27T09:22:14Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Cuervo, Henar
author
Mühleder, Severin
author
Garcia-Gonzalez, Irene
author
Benedito, Rui
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Fundación La Caixa
funder
Comunidad de Madrid (España)
2024-05-09T13:11:26Z
2024-05-09T13:11:26Z
2023-12
Curr Opin Cell Biol. 2023 Dec:85:102254.
10.1016/j.ceb.2023.102254
1879-0410
Current opinion in cell biology
37832167
http://hdl.handle.net/20.500.12105/19330
Vessel formation and differentiation to a proper hierarchical vasculature requires a coordinated effort from endothelial and mural cells. Over the last decade Notch was identified as a key player in this process by promoting vascular arterialization and modulating endothelial tip-stalk phenotypes. Recent work has identified that Notch fine-tunes the diverse endothelial phenotypes through regulation of canonical cell-cycle and metabolism regulators, such as ERK and Myc. During arterialization, Notch signaling inhibits the cell-cycle and metabolism of endothelial cells which coincides with the acquisition of arterial identity. During angiogenesis, the same molecular machinery prevents the hypermitogenic arrest and excessive sprouting of vessels. Notch also signals in pericytes and smooth muscle cells promoting vascular coverage and maturation. Here, we will review the latest findings on how Notch signals regulate the differentiation and interactions among vascular cells during organ development and homeostasis.
eng
Notch-mediated cellular interactions between vascular cells.
journal article
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URL
https://repisalud.isciii.es/bitstreams/b36d9d83-4d8a-4943-9222-2ed78fb5d4b1/download
File
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Notch_mediated cellular_Curr Opin Cell Biol_2023.pdf
URL
https://repisalud.isciii.es/bitstreams/fee970b0-7038-47fc-b65f-0d1a3bdc3015/download
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MD5
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Notch_mediated cellular_Curr Opin Cell Biol_2023.pdf.txt