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oai:repisalud.isciii.es:20.500.12105/193302024-09-27T09:22:14Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Cuervo, Henar author Mühleder, Severin author Garcia-Gonzalez, Irene author Benedito, Rui author 2023-12 Vessel formation and differentiation to a proper hierarchical vasculature requires a coordinated effort from endothelial and mural cells. Over the last decade Notch was identified as a key player in this process by promoting vascular arterialization and modulating endothelial tip-stalk phenotypes. Recent work has identified that Notch fine-tunes the diverse endothelial phenotypes through regulation of canonical cell-cycle and metabolism regulators, such as ERK and Myc. During arterialization, Notch signaling inhibits the cell-cycle and metabolism of endothelial cells which coincides with the acquisition of arterial identity. During angiogenesis, the same molecular machinery prevents the hypermitogenic arrest and excessive sprouting of vessels. Notch also signals in pericytes and smooth muscle cells promoting vascular coverage and maturation. Here, we will review the latest findings on how Notch signals regulate the differentiation and interactions among vascular cells during organ development and homeostasis. Curr Opin Cell Biol. 2023 Dec:85:102254. 10.1016/j.ceb.2023.102254 1879-0410 Current opinion in cell biology 37832167 http://hdl.handle.net/20.500.12105/19330 Notch-mediated cellular interactions between vascular cells.