2026-05-25T08:32:29Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/193282024-09-21T13:37:54Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Simon-Chica, Ana
author
Wülfers, Eike M
author
Kohl, Peter
funder
Fundación La Caixa
2024-05-09T12:40:13Z
2024-05-09T12:40:13Z
2023-09-01
Am J Physiol Heart Circ Physiol. 2023 Sep 1;325(3):H475-H491.
10.1152/ajpheart.00184.2023
1522-1539
American journal of physiology. Heart and circulatory physiology
37417876
http://hdl.handle.net/20.500.12105/19328
Although cardiac action potential (AP) generation and propagation have traditionally been attributed exclusively to cardiomyocytes (CM), other cell types in the heart are also capable of forming electrically conducting junctions. Interactions between CM and nonmyocytes (NM) enable and modulate each other's activity. This review provides an overview of the current understanding of heterocellular electrical communication in the heart. Although cardiac fibroblasts were initially thought to be electrical insulators, recent studies have demonstrated that they form functional electrical connections with CM in situ. Other NM, such as macrophages, have also been recognized as contributing to cardiac electrophysiology and arrhythmogenesis. Novel experimental tools have enabled the investigation of cell-specific activity patterns in native cardiac tissue, which is expected to yield exciting new insights into the development of novel or improved diagnostic and therapeutic strategies.
eng
Nonmyocytes as electrophysiological contributors to cardiac excitation and conduction.
review article
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Nonmyocytes as electrophysiological_Am J Physiol Heart Circ Physiol_2023.pdf
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22c9c63630b03333fa7c3a9bd21e752c
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Nonmyocytes as electrophysiological_Am J Physiol Heart Circ Physiol_2023.pdf.txt