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00925njm 22002777a 4500 dc Simon-Chica, Ana author Wülfers, Eike M author Kohl, Peter author 2023-09-01 Although cardiac action potential (AP) generation and propagation have traditionally been attributed exclusively to cardiomyocytes (CM), other cell types in the heart are also capable of forming electrically conducting junctions. Interactions between CM and nonmyocytes (NM) enable and modulate each other's activity. This review provides an overview of the current understanding of heterocellular electrical communication in the heart. Although cardiac fibroblasts were initially thought to be electrical insulators, recent studies have demonstrated that they form functional electrical connections with CM in situ. Other NM, such as macrophages, have also been recognized as contributing to cardiac electrophysiology and arrhythmogenesis. Novel experimental tools have enabled the investigation of cell-specific activity patterns in native cardiac tissue, which is expected to yield exciting new insights into the development of novel or improved diagnostic and therapeutic strategies. Am J Physiol Heart Circ Physiol. 2023 Sep 1;325(3):H475-H491. http://hdl.handle.net/20.500.12105/19328 37417876 10.1152/ajpheart.00184.2023 1522-1539 American journal of physiology. Heart and circulatory physiology Nonmyocytes as electrophysiological contributors to cardiac excitation and conduction.