2026-04-29T12:23:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/192852024-09-27T07:57:24Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Gomez-Bris, Raquel
author
Saez, Angela
author
Herrero-Fernandez, Beatriz
author
Rius, Cristina
author
Sanchez-Martinez, Hector
author
Gonzalez-Granado, Jose M
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
funder
Comunidad de Madrid (España)
2024-05-08T08:19:03Z
2024-05-08T08:19:03Z
2023-01-31
Int J Mol Sci. 2023 Jan 31;24(3):2696.
10.3390/ijms24032696
1422-0067
International journal of molecular sciences
36769019
http://hdl.handle.net/20.500.12105/19285
Inflammatory bowel disease (IBD) is an umbrella term for the chronic immune-mediated idiopathic inflammation of the gastrointestinal tract, manifesting as Crohn's disease (CD) or ulcerative colitis (UC). IBD is characterized by exacerbated innate and adaptive immunity in the gut in association with microbiota dysbiosis and the disruption of the intestinal barrier, resulting in increased bacterial exposure. In response to signals from microorganisms and damaged tissue, innate immune cells produce inflammatory cytokines and factors that stimulate T and B cells of the adaptive immune system, and a prominent characteristic of IBD patients is the accumulation of inflammatory T-cells and their proinflammatory-associated cytokines in intestinal tissue. Upon antigen recognition and activation, CD4 T-cells differentiate towards a range of distinct phenotypes: T helper(h)1, Th2, Th9, Th17, Th22, T follicular helper (Tfh), and several types of T-regulatory cells (Treg). T-cells are generated according to and adapt to microenvironmental conditions and participate in a complex network of interactions among other immune cells that modulate the further progression of IBD. This review examines the role of the CD4 T-cells most relevant to IBD, highlighting how these cells adapt to the environment and interact with other cell populations to promote or inhibit the development of IBD.
eng
CD4 T-Cell Subsets and the Pathophysiology of Inflammatory Bowel Disease.
journal article
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CD4 T_Cell Subsets and the Pathophysiology_Int J Mol Sci_2023.pdf
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https://repisalud.isciii.es/bitstreams/fae46086-d1a8-4a14-a0cb-f441c024c276/download
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CD4 T_Cell Subsets and the Pathophysiology_Int J Mol Sci_2023.pdf.txt