2026-05-22T08:53:50Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/192742024-09-27T09:15:58Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Coats, Caroline J
author
Maron, Martin S
author
Abraham, Theodore P
author
Olivotto, Iacopo
author
Lee, Matthew M Y
author
Arad, Michael
author
Cardim, Nuno
author
Ma, Chang-Sheng
author
Choudhury, Lubna
author
Düngen, Hans-Dirk
author
Garcia-Pavia, Pablo
author
Hagège, Albert A
author
Lewis, Gregory D
author
Michels, Michelle
author
Oreziak, Artur
author
Owens, Anjali T
author
Tfelt-Hansen, Jacob
author
Veselka, Josef
author
Watkins, Hugh C
author
Heitner, Stephen B
author
Jacoby, Daniel L
author
Kupfer, Stuart
author
Malik, Fady I
author
Meng, Lisa
author
Wohltman, Amy
author
Masri, Ahmad
2024-05-07T10:57:57Z
2024-05-07T10:57:57Z
2024-01
JACC Heart Fail. 2024 Jan;12(1):199-215.
10.1016/j.jchf.2023.10.004
2213-1787
JACC. Heart failure
38032573
http://hdl.handle.net/20.500.12105/19274
Patients with obstructive hypertrophic cardiomyopathy (oHCM) have increased risk of arrhythmia, stroke, heart failure, and sudden death. Contemporary management of oHCM has decreased annual hospitalization and mortality rates, yet patients have worsening health-related quality of life due to impaired exercise capacity and persistent residual symptoms. Here we consider the design of clinical trials evaluating potential oHCM therapies in the context of SEQUOIA-HCM (Safety, Efficacy, and Quantitative Understanding of Obstruction Impact of Aficamten in HCM). This large, phase 3 trial is now fully enrolled (N = 282). Baseline characteristics reflect an ethnically diverse population with characteristics typical of patients encountered clinically with substantial functional and symptom burden. The study will assess the effect of aficamten vs placebo, in addition to standard-of-care medications, on functional capacity and symptoms over 24 weeks. Future clinical trials could model the approach in SEQUOIA-HCM to evaluate the effect of potential therapies on the burden of oHCM. (Safety, Efficacy, and Quantitative Understanding of Obstruction Impact of Aficamten in HCM [SEQUOIA-HCM]; NCT05186818).
eng
Exercise Capacity in Patients With Obstructive Hypertrophic Cardiomyopathy: SEQUOIA-HCM Baseline Characteristics and Study Design.
editorial
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URL
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application/pdf
Exercise Capacity in Patients With Obstructive_JACC Heart Fail_2024.pdf
URL
https://repisalud.isciii.es/bitstreams/4eafb1d3-4ec2-4b1c-9713-7192628f9a84/download
File
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text/plain
Exercise Capacity in Patients With Obstructive_JACC Heart Fail_2024.pdf.txt