2026-05-10T16:56:30Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/191752025-04-08T11:08:15Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16980col_20.500.12105_16982col_20.500.12105_16984col_20.500.12105_16988col_20.500.12105_25179
Repisalud
author
Monzon-Fernandez, Sara
author
Varona Fernandez, Sarai
author
Negredo, Anabel
author
Vidal-Freire, Santiago
author
Patiño-Galindo, Juan Angel
author
Ferressini-Gerpe, Natalia
author
Zaballos, Ángel
author
Orviz, Eva
author
Ayerdi, Oskar
author
Muñoz-Gómez, Ana
author
Delgado-Iribarren, Alberto
author
Estrada, Vicente
author
Garcia-Amil, Cristina
author
Molero-Sanz, Francisca
author
Sánchez-Mora, Patricia
author
Torres, Montserrat
author
Vazquez, Ana
author
Galán, Juan Carlos
author
Torres, Ignacio
author
Causse Del Río, Manuel
author
Merino-Diaz, Laura
author
López, Marcos
author
Galar, Alicia
author
Cardeñoso, Laura
author
Gutiérrez, Almudena
author
Loras, Cristina
author
Escribano, Isabel
author
Alvarez-Argüelles, Marta E
author
Del Río, Leticia
author
Simón, María
author
Meléndez, María Angeles
author
Camacho, Juan
author
Herrero, Laura
author
Jimenez Sancho, Maria Pilar
author
Navarro-Rico, María Luisa
author
Jado, Isabel
author
Giannetti, Elaina
author
Kuhn, Jens H
author
Sanchez-Lockhart, Mariano
author
Di Paola, Nicholas
author
Kugelman, Jeffrey R
author
Guerra, Susana
author
García-Sastre, Adolfo
author
Cuesta de la Plaza, Isabel
author
Sánchez-Seco, María Paz
author
Palacios, Gustavo
funder
Instituto de Salud Carlos III
funder
Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas)
funder
Icahn School of Medicine at Mount Sinai
funder
NIH - National Institute of Allergy and Infectious Diseases (NIAID) (Estados Unidos)
2024-04-23T07:56:53Z
2024-04-23T07:56:53Z
2024-04-18
Nat Commun. 2024 Apr 18;15(1):3059.
10.1038/s41467-024-46949-7
2041-1723
Nature communications
38637500
http://hdl.handle.net/20.500.12105/19175
The 2023 monkeypox (mpox) epidemic was caused by a subclade IIb descendant of a monkeypox virus (MPXV) lineage traced back to Nigeria in 1971. Person-to-person transmission appears higher than for clade I or subclade IIa MPXV, possibly caused by genomic changes in subclade IIb MPXV. Key genomic changes could occur in the genome's low-complexity regions (LCRs), which are challenging to sequence and are often dismissed as uninformative. Here, using a combination of highly sensitive techniques, we determine a high-quality MPXV genome sequence of a representative of the current epidemic with LCRs resolved at unprecedented accuracy. This reveals significant variation in short tandem repeats within LCRs. We demonstrate that LCR entropy in the MPXV genome is significantly higher than that of single-nucleotide polymorphisms (SNPs) and that LCRs are not randomly distributed. In silico analyses indicate that expression, translation, stability, or function of MPXV orthologous poxvirus genes (OPGs), including OPG153, OPG204, and OPG208, could be affected in a manner consistent with the established "genomic accordion" evolutionary strategies of orthopoxviruses. We posit that genomic studies focusing on phenotypic MPXV differences should consider LCR variability.
eng
Monkeypox virus genomic accordion strategies
research article
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